TY - JOUR
T1 - Association between arsenic exposure from drinking water and hematuria
T2 - Results from the Health Effects of Arsenic Longitudinal Study
AU - McClintock, Tyler R.
AU - Chen, Yu
AU - Parvez, Faruque
AU - Makarov, Danil V.
AU - Ge, Wenzhen
AU - Islam, Tariqul
AU - Ahmed, Alauddin
AU - Rakibuz-Zaman, Muhammad
AU - Hasan, Rabiul
AU - Sarwar, Golam
AU - Slavkovich, Vesna
AU - Bjurlin, Marc A.
AU - Graziano, Joseph H.
AU - Ahsan, Habibul
N1 - Funding Information:
This work was supported by the National Institutes of Health (grants R01 ES017541 , R01 CA107431 , P42 ES010349 , and P30 ES000260 ) and in part by grant UL1 TR000038 from the National Center for the Advancement of Translational Science (NCATS), National Institutes of Health .
PY - 2014/4/1
Y1 - 2014/4/1
N2 - Arsenic (As) exposure has been associated with both urologic malignancy and renal dysfunction; however, its association with hematuria is unknown. We evaluated the association between drinking water As exposure and hematuria in 7843 men enrolled in the Health Effects of Arsenic Longitudinal Study (HEALS). Cross-sectional analysis of baseline data was conducted with As exposure assessed in both well water and urinary As measurements, while hematuria was measured using urine dipstick. Prospective analyses with Cox proportional regression models were based on urinary As and dipstick measurements obtained biannually since baseline up to six years. At baseline, urinary As was significantly related to prevalence of hematuria (P-trend. <. 0.01), with increasing quintiles of exposure corresponding with respective prevalence odds ratios of 1.00 (reference), 1.29 (95% CI: 1.04-1.59), 1.41 (95% CI: 1.15-1.74), 1.46 (95% CI: 1.19-1.79), and 1.56 (95% CI: 1.27-1.91). Compared to those with relatively little absolute urinary As change during follow-up (-. 10.40 to 41.17. μg/l), hazard ratios for hematuria were 0.99 (95% CI: 0.80-1.22) and 0.80 (95% CI: 0.65-0.99) for those whose urinary As decreased by >. 47.49. μg/l and 10.87 to 47.49. μg/l since last visit, respectively, and 1.17 (95% CI: 0.94-1.45) and 1.36 (95% CI: 1.10-1.66) for those with between-visit increases of 10.40 to 41.17. μg/l and >. 41.17. μg/l, respectively. These data indicate a positive association of As exposure with both prevalence and incidence of dipstick hematuria. This exposure effect appears modifiable by relatively short-term changes in drinking water As.
AB - Arsenic (As) exposure has been associated with both urologic malignancy and renal dysfunction; however, its association with hematuria is unknown. We evaluated the association between drinking water As exposure and hematuria in 7843 men enrolled in the Health Effects of Arsenic Longitudinal Study (HEALS). Cross-sectional analysis of baseline data was conducted with As exposure assessed in both well water and urinary As measurements, while hematuria was measured using urine dipstick. Prospective analyses with Cox proportional regression models were based on urinary As and dipstick measurements obtained biannually since baseline up to six years. At baseline, urinary As was significantly related to prevalence of hematuria (P-trend. <. 0.01), with increasing quintiles of exposure corresponding with respective prevalence odds ratios of 1.00 (reference), 1.29 (95% CI: 1.04-1.59), 1.41 (95% CI: 1.15-1.74), 1.46 (95% CI: 1.19-1.79), and 1.56 (95% CI: 1.27-1.91). Compared to those with relatively little absolute urinary As change during follow-up (-. 10.40 to 41.17. μg/l), hazard ratios for hematuria were 0.99 (95% CI: 0.80-1.22) and 0.80 (95% CI: 0.65-0.99) for those whose urinary As decreased by >. 47.49. μg/l and 10.87 to 47.49. μg/l since last visit, respectively, and 1.17 (95% CI: 0.94-1.45) and 1.36 (95% CI: 1.10-1.66) for those with between-visit increases of 10.40 to 41.17. μg/l and >. 41.17. μg/l, respectively. These data indicate a positive association of As exposure with both prevalence and incidence of dipstick hematuria. This exposure effect appears modifiable by relatively short-term changes in drinking water As.
KW - Arsenic
KW - Bangladesh
KW - Environmental epidemiology
KW - Hematuria
KW - Mass screening
KW - Urologic neoplasms
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UR - http://www.scopus.com/inward/citedby.url?scp=84896048674&partnerID=8YFLogxK
U2 - 10.1016/j.taap.2014.01.015
DO - 10.1016/j.taap.2014.01.015
M3 - Article
C2 - 24486435
AN - SCOPUS:84896048674
VL - 276
SP - 21
EP - 27
JO - Toxicology and Applied Pharmacology
JF - Toxicology and Applied Pharmacology
SN - 0041-008X
IS - 1
ER -