TY - JOUR
T1 - Association between arsenic exposure from drinking water and plasma levels of cardiovascular markers
AU - Wu, Fen
AU - Jasmine, Farzana
AU - Kibriya, Muhammad G.
AU - Liu, Mengling
AU - Wójcik, Oktawia
AU - Parvez, Faruque
AU - Rahaman, Ronald
AU - Roy, Shantanu
AU - Paul-Brutus, Rachelle
AU - Segers, Stephanie
AU - Slavkovich, Vesna
AU - Islam, Tariqul
AU - Levy, Diane
AU - Mey, Jacob L.
AU - Van Geen, Alexander
AU - Graziano, Joseph H.
AU - Ahsan, Habibul
AU - Chen, Yu
PY - 2012/6/15
Y1 - 2012/6/15
N2 - The authors conducted a cross-sectional study to assess the relation between arsenic exposure fromdrinking water and plasma levels of markers of systemic inflammation and endothelial dysfunction (matrix metalloproteinase-9, myeloperoxidase, plasminogen activator inhibitor-1, soluble E-selectin, soluble intercellular adhesion molecule-1 (ICAM-1), and soluble vascular adhesion molecule-1 (VCAM-1)) using baseline data from 668 participants (age, >30 years) in the Health Effects of Arsenic Longitudinal Study in Bangladesh (2007-2008). Both well water arsenic and urinary arsenic were positively associated with plasma levels of soluble VCAM-1. For every 1-unit increase in log-transformed well water arsenic (ln μg/L) and urinary arsenic (ln μg/g creatinine), plasma soluble VCAM-1 was 1.02 (95%confidence interval: 1.01, 1.03) and 1.04 (95%confidence interval: 1.01, 1.07) times greater, respectively. There was a significant interaction between arsenic exposure and higher bodymass index, such that the increased levels of plasminogen activator inhibitor-1 and soluble VCAM-1 associated with arsenic exposure were stronger among people with higher body mass index. The findings indicate an effect of chronic arsenic exposure from drinking water on vascular inflammation and endothelial dysfunction that could be modified by body mass index and also suggest a potential mechanism underlying the association between arsenic exposure and cardiovascular disease.
AB - The authors conducted a cross-sectional study to assess the relation between arsenic exposure fromdrinking water and plasma levels of markers of systemic inflammation and endothelial dysfunction (matrix metalloproteinase-9, myeloperoxidase, plasminogen activator inhibitor-1, soluble E-selectin, soluble intercellular adhesion molecule-1 (ICAM-1), and soluble vascular adhesion molecule-1 (VCAM-1)) using baseline data from 668 participants (age, >30 years) in the Health Effects of Arsenic Longitudinal Study in Bangladesh (2007-2008). Both well water arsenic and urinary arsenic were positively associated with plasma levels of soluble VCAM-1. For every 1-unit increase in log-transformed well water arsenic (ln μg/L) and urinary arsenic (ln μg/g creatinine), plasma soluble VCAM-1 was 1.02 (95%confidence interval: 1.01, 1.03) and 1.04 (95%confidence interval: 1.01, 1.07) times greater, respectively. There was a significant interaction between arsenic exposure and higher bodymass index, such that the increased levels of plasminogen activator inhibitor-1 and soluble VCAM-1 associated with arsenic exposure were stronger among people with higher body mass index. The findings indicate an effect of chronic arsenic exposure from drinking water on vascular inflammation and endothelial dysfunction that could be modified by body mass index and also suggest a potential mechanism underlying the association between arsenic exposure and cardiovascular disease.
KW - Arsenic
KW - Bangladesh
KW - Cardiovascular disease
KW - Cross-sectional studies
KW - Environmental exposure
KW - Inflammation
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U2 - 10.1093/aje/kwr464
DO - 10.1093/aje/kwr464
M3 - Article
C2 - 22534204
AN - SCOPUS:84862500456
SN - 0002-9262
VL - 175
SP - 1252
EP - 1261
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
IS - 12
ER -