Association between arsenic exposure from drinking water and plasma levels of soluble cell adhesion molecules

Yu Chen, Regina M. Santella, Muhammad G. Kibriya, Qiao Wang, Maya Kappil, Wendy J. Verret, Joseph H. Graziano, Habibul Ahsan

Research output: Contribution to journalArticle

Abstract

Background: Epidemiologic studies of cardiovascular disease risk factors and appropriate biomarkers in populations exposed to a wide range of arsenic levels are a public health research priority. Objective: We investigated the relationship between inorganic arsenic exposure from drinking water and plasma levels of soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular adhesion molecule-1 (sVCAM-1), both markers of endothelial dysfunction and vascular inflammation, in an arsenic-exposed population in Araihazar, Bangladesh. Methods: The study participants included 115 individuals with arsenic-related skin lesions participating in a 2 × 2 randomized, placebo-controlled, double-blind trial of vitamin E and selenium supplementation. Arsenic exposure status and plasma levels of sICAM-1 and sVCAM-1 were assessed at baseline and after 6 months of follow-up. Results: Baseline well arsenic, a long-term measure of arsenic exposure, was positively associated with baseline levels of both sICAM-1 and sVCAM-1 and with changes in the two markers over time. At baseline, for every 1-μg/L increase in well arsenic there was an increase of 0.10 ng/mL [95% confidence interval (CI), 0.00-0.20] and 0.33 ng/mL (95% CI, 0.15-0.51) in plasma sICAM-1 and sVCAM-1, respectively. Every 1-μg/L increase in well arsenic was associated with a rise of 0.11 ng/mL (95% CI, 0.01-0.22) and 0.17 ng/mL (95% CI, 0.00-0.35) in sICAM-1 and sVCAM-1 from baseline to follow-up, respectively, in spite of recent changes in urinary arsenic as well as vitamin E and selenium supplementation during the study period. Conclusions: The findings indicate an effect of chronic arsenic exposure from drinking water on vascular inflammation that persists over time and also suggest a potential mechanism underlying the association between arsenic exposure and cardiovascular disease.

Original languageEnglish (US)
Pages (from-to)1415-1420
Number of pages6
JournalEnvironmental health perspectives
Volume115
Issue number10
DOIs
StatePublished - Oct 2007

Keywords

  • Arsenic
  • Bangladesh
  • Cardiovascular disease
  • Endothelial dysfunction
  • Environmental epidemiology
  • Epidemiology
  • Vascular inflammation

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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    Chen, Y., Santella, R. M., Kibriya, M. G., Wang, Q., Kappil, M., Verret, W. J., Graziano, J. H., & Ahsan, H. (2007). Association between arsenic exposure from drinking water and plasma levels of soluble cell adhesion molecules. Environmental health perspectives, 115(10), 1415-1420. https://doi.org/10.1289/ehp.10277