Association between arsenic exposure from drinking water and proteinuria: Results from the health effects of arsenic longitudinal study

Yu Chen, Faruque Parvez, Mengling Liu, Gene R. Pesola, Mary V. Gamble, Vesna Slavkovich, Tariqul Islam, Alauddin Ahmed, Rabiul Hasan, Joseph H. Graziano, Habibul Ahsan

Research output: Contribution to journalArticle

Abstract

Background :Proteinuria has been recognized as a marker for an increased risk of chronic renal disease. It is unclear whether arsenic (As) exposure from drinking water is associated with proteinuria. Methods :We evaluated the association between As exposure from drinking water and proteinuria in 11 122 participants in the Health Effects of Arsenic Longitudinal Study (HEALS). Proteinuria was detected by urinary dipstick tests at baseline and at 2-year intervals. As exposure variables included baseline well As and changes in urinary As during follow-up modelled as time-dependent variables in the analyses. Results: At baseline, well As was positively related to prevalence of proteinuria; prevalence odds ratios (PORs) for proteinuria in increasing quintiles of well As (47, 8-39, 40-91, 92-179 and 180-864 mg/l) were 1.00 (ref), POR 0.99 [95% confidence interval (CI) 0.77-1.27], POR 1.23 (95% CI 0.97-1.57), POR 1.50 (95% CI 1.18-1.89) and POR 1.59 (95% CI 1.26-2.00) (P for trend <0.01). Hazard ratios for incidence of proteinuria were POR 0.83 (95% CI 0.67-1.03) and POR 0.91 (95% CI 0.74-1.12) for participants with a decreasing level of 470 and 17-70 mg/l in urinary As over time, respectively, and were POR 1.17 (95% CI 0.97-1.42) and POR 1.42 (95% CI 1.16-1.73) for participants with an increasing level of 16-68 and468 mg/l in urinary As over time, respectively, compared with the group with relatively little changes in urinary As as the reference group (urinary As -16 to 15 mg/l). Conclusion :The findings suggest that there are adverse effects of As exposure on the risk of proteinuria and the effects are modifiable by recent changes in As exposure. Published by Oxford University Press on behalf of the International Epidemiological Association.

Original languageEnglish (US)
Pages (from-to)828-835
Number of pages8
JournalInternational Journal of Epidemiology
Volume40
Issue number3
DOIs
StatePublished - Jun 2011

Keywords

  • Arsenic exposure
  • Bangladesh
  • Environmental epidemiology
  • Proteinuria

ASJC Scopus subject areas

  • Epidemiology

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    Chen, Y., Parvez, F., Liu, M., Pesola, G. R., Gamble, M. V., Slavkovich, V., Islam, T., Ahmed, A., Hasan, R., Graziano, J. H., & Ahsan, H. (2011). Association between arsenic exposure from drinking water and proteinuria: Results from the health effects of arsenic longitudinal study. International Journal of Epidemiology, 40(3), 828-835. https://doi.org/10.1093/ije/dyr022