Association between changes in suspicious prostate lesions on serial MRI examinations and follow-up biopsy results

Andrew B. Rosenkrantz; Samuel L. Rice; Natasha E. Wehrli; Fang Ming Deng; Samir S. Taneja

doi:10.1016/j.clinimag.2014.08.008

Association between changes in suspicious prostate lesions on serial MRI examinations and follow-up biopsy results

Andrew B. Rosenkrantz, Samuel L. Rice, Natasha E. Wehrli, Fang Ming Deng, Samir S. Taneja

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

We assessed changes in prostate lesions on serial magnetic resonance imaging (MRI) examinations in predicting biopsy results. Fifty-five men undergoing two prostate MRI examinations ≥. 6. months apart, followed by targeted biopsy, were included. Two radiologists assessed dominant lesions for an increase in size or suspicion score. Progression on MRI had lower sensitivity (23.5%-35.3%) and higher specificity (76.2%-90.5%) than prostate-specific antigen (PSA) velocity (sensitivity 70.6%, specificity 52.4%) for predicting positive biopsy. Highest accuracy was achieved by PSA velocity (63.6%) for positive biopsy, and by MRI (65.5%-72.7%) for Gleason >. 6 tumor. Findings support lesion progression on MRI serving as a basis for performing subsequent targeted biopsy.

Original language	English (US)
Pages (from-to)	264-269
Number of pages	6
Journal	Clinical Imaging
Volume	39
Issue number	2
DOIs	https://doi.org/10.1016/j.clinimag.2014.08.008
State	Published - Mar 1 2015

Keywords

Biopsy
MRI
PSA
Prostate cancer

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1016/j.clinimag.2014.08.008

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title = "Association between changes in suspicious prostate lesions on serial MRI examinations and follow-up biopsy results",

abstract = "We assessed changes in prostate lesions on serial magnetic resonance imaging (MRI) examinations in predicting biopsy results. Fifty-five men undergoing two prostate MRI examinations ≥. 6. months apart, followed by targeted biopsy, were included. Two radiologists assessed dominant lesions for an increase in size or suspicion score. Progression on MRI had lower sensitivity (23.5%-35.3%) and higher specificity (76.2%-90.5%) than prostate-specific antigen (PSA) velocity (sensitivity 70.6%, specificity 52.4%) for predicting positive biopsy. Highest accuracy was achieved by PSA velocity (63.6%) for positive biopsy, and by MRI (65.5%-72.7%) for Gleason >. 6 tumor. Findings support lesion progression on MRI serving as a basis for performing subsequent targeted biopsy.",

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author = "Rosenkrantz, {Andrew B.} and Rice, {Samuel L.} and Wehrli, {Natasha E.} and Deng, {Fang Ming} and Taneja, {Samir S.}",

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AU - Wehrli, Natasha E.

AU - Deng, Fang Ming

AU - Taneja, Samir S.

PY - 2015/3/1

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N2 - We assessed changes in prostate lesions on serial magnetic resonance imaging (MRI) examinations in predicting biopsy results. Fifty-five men undergoing two prostate MRI examinations ≥. 6. months apart, followed by targeted biopsy, were included. Two radiologists assessed dominant lesions for an increase in size or suspicion score. Progression on MRI had lower sensitivity (23.5%-35.3%) and higher specificity (76.2%-90.5%) than prostate-specific antigen (PSA) velocity (sensitivity 70.6%, specificity 52.4%) for predicting positive biopsy. Highest accuracy was achieved by PSA velocity (63.6%) for positive biopsy, and by MRI (65.5%-72.7%) for Gleason >. 6 tumor. Findings support lesion progression on MRI serving as a basis for performing subsequent targeted biopsy.

AB - We assessed changes in prostate lesions on serial magnetic resonance imaging (MRI) examinations in predicting biopsy results. Fifty-five men undergoing two prostate MRI examinations ≥. 6. months apart, followed by targeted biopsy, were included. Two radiologists assessed dominant lesions for an increase in size or suspicion score. Progression on MRI had lower sensitivity (23.5%-35.3%) and higher specificity (76.2%-90.5%) than prostate-specific antigen (PSA) velocity (sensitivity 70.6%, specificity 52.4%) for predicting positive biopsy. Highest accuracy was achieved by PSA velocity (63.6%) for positive biopsy, and by MRI (65.5%-72.7%) for Gleason >. 6 tumor. Findings support lesion progression on MRI serving as a basis for performing subsequent targeted biopsy.

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Association between changes in suspicious prostate lesions on serial MRI examinations and follow-up biopsy results

Abstract

Keywords

ASJC Scopus subject areas

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