Association between changes in suspicious prostate lesions on serial MRI examinations and follow-up biopsy results

Andrew B. Rosenkrantz, Samuel L. Rice, Natasha E. Wehrli, Fang Ming Deng, Samir S. Taneja

    Research output: Contribution to journalArticle

    Abstract

    We assessed changes in prostate lesions on serial magnetic resonance imaging (MRI) examinations in predicting biopsy results. Fifty-five men undergoing two prostate MRI examinations ≥. 6. months apart, followed by targeted biopsy, were included. Two radiologists assessed dominant lesions for an increase in size or suspicion score. Progression on MRI had lower sensitivity (23.5%-35.3%) and higher specificity (76.2%-90.5%) than prostate-specific antigen (PSA) velocity (sensitivity 70.6%, specificity 52.4%) for predicting positive biopsy. Highest accuracy was achieved by PSA velocity (63.6%) for positive biopsy, and by MRI (65.5%-72.7%) for Gleason >. 6 tumor. Findings support lesion progression on MRI serving as a basis for performing subsequent targeted biopsy.

    Original languageEnglish (US)
    Pages (from-to)264-269
    Number of pages6
    JournalClinical Imaging
    Volume39
    Issue number2
    DOIs
    StatePublished - Mar 1 2015

    Keywords

    • Biopsy
    • MRI
    • PSA
    • Prostate cancer

    ASJC Scopus subject areas

    • Radiology Nuclear Medicine and imaging

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