TY - JOUR
T1 - Association between gastric helicobacter pylori colonization and glycated hemoglobin levels
AU - Chen, Yu
AU - Blaser, Martin J.
N1 - Funding Information:
Financial support. This work was supported by grants from the National Institutes of Health (grants ES000260, CA016087, RO1GM63270, and R01DK090989) and the Diane Belfer Program in Human Microbial Ecology. Potential conflicts of interest. All authors: No reported conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.
PY - 2012/4/15
Y1 - 2012/4/15
N2 - Background. Few studies have evaluated the potential influence of Helicobacter pylori on biomarkers for diabetes. Methods. We conducted cross-sectional analyses using data from 7417 participants in the National Health and Nutrition Examination Survey (NHANES) III (aged ≥18 years) and 6072 participants in NHANES 1999-2000 (aged ≥3 years) to assess the association between H. pylori and levels of glycosylated hemoglobin (HbA1c). Results. There was no association between H. pylori and history of self-reported diabetes. Helicobacter pylori seropositivity, especially H. pylori cagA positivity, was positively associated (P <. 01, NHANES III; P =. 02, NHANES 1999-2000) with HbA1c levels after excluding individuals with history of diabetes and controlling for potential confounders. There was also a synergistic interaction between H. pylori and higher body mass index (BMI), such that increased levels of HbA1c associated with having both H. pylori and higher BMI were greater than the sum of their individual effects (P for interaction <. 01). This interaction was observed consistently in both NHANES III and NHANES 1999-2000 and for H. pylori cagA positivity in NHANES III. Conclusions. The findings indicate a role of H. pylori in impaired glucose tolerance in adults that may be potentiated by higher BMI level.
AB - Background. Few studies have evaluated the potential influence of Helicobacter pylori on biomarkers for diabetes. Methods. We conducted cross-sectional analyses using data from 7417 participants in the National Health and Nutrition Examination Survey (NHANES) III (aged ≥18 years) and 6072 participants in NHANES 1999-2000 (aged ≥3 years) to assess the association between H. pylori and levels of glycosylated hemoglobin (HbA1c). Results. There was no association between H. pylori and history of self-reported diabetes. Helicobacter pylori seropositivity, especially H. pylori cagA positivity, was positively associated (P <. 01, NHANES III; P =. 02, NHANES 1999-2000) with HbA1c levels after excluding individuals with history of diabetes and controlling for potential confounders. There was also a synergistic interaction between H. pylori and higher body mass index (BMI), such that increased levels of HbA1c associated with having both H. pylori and higher BMI were greater than the sum of their individual effects (P for interaction <. 01). This interaction was observed consistently in both NHANES III and NHANES 1999-2000 and for H. pylori cagA positivity in NHANES III. Conclusions. The findings indicate a role of H. pylori in impaired glucose tolerance in adults that may be potentiated by higher BMI level.
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U2 - 10.1093/infdis/jis106
DO - 10.1093/infdis/jis106
M3 - Article
C2 - 22427676
AN - SCOPUS:84859012786
SN - 0022-1899
VL - 205
SP - 1195
EP - 1202
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 8
ER -