TY - JOUR
T1 - Association mapping of local climate-sensitive quantitative trait loci in Arabidopsis thaliana
AU - Li, Yan
AU - Huang, Yu
AU - Bergelson, Joy
AU - Nordborg, Magnus
AU - Borevitz, Justin O.
PY - 2010/12/7
Y1 - 2010/12/7
N2 - Flowering time (FT) is the developmental transition coupling an internal genetic program with external local and seasonal climate cues. The genetic loci sensitive to predictable environmental signals underlie local adaptation.Wedissected natural variation in FT across a new global diversity set of 473 unique accessions, with >12,000 plants across two seasonal plantings in each of two simulated local climates, Spain andSweden. Genome-wide associationmappingwas carried outwith 213,497 SNPs.Atotal of 12 FT candidate quantitative trait loci (QTL)were fine-mapped in two independent studies, including 4 located within ±10 kb of previously cloned FT alleles and 8 novel loci. All QTL show sensitivity to planting season and/or simulated location in a multi-QTL mixed model. Alleles at four QTL were significantly correlated with latitude of origin, implying past selection for faster flowering in southern locations. Finally, maximum seed yield was observed at an optimal FT unique to each season and location, with four FT QTL directly controlling yield. Our results suggest that these major, environmentally sensitive FT QTL play an important role in spatial and temporal adaptation.
AB - Flowering time (FT) is the developmental transition coupling an internal genetic program with external local and seasonal climate cues. The genetic loci sensitive to predictable environmental signals underlie local adaptation.Wedissected natural variation in FT across a new global diversity set of 473 unique accessions, with >12,000 plants across two seasonal plantings in each of two simulated local climates, Spain andSweden. Genome-wide associationmappingwas carried outwith 213,497 SNPs.Atotal of 12 FT candidate quantitative trait loci (QTL)were fine-mapped in two independent studies, including 4 located within ±10 kb of previously cloned FT alleles and 8 novel loci. All QTL show sensitivity to planting season and/or simulated location in a multi-QTL mixed model. Alleles at four QTL were significantly correlated with latitude of origin, implying past selection for faster flowering in southern locations. Finally, maximum seed yield was observed at an optimal FT unique to each season and location, with four FT QTL directly controlling yield. Our results suggest that these major, environmentally sensitive FT QTL play an important role in spatial and temporal adaptation.
KW - Efficient mixed-model association
KW - Genotype by environment interaction
KW - Life history
KW - Pleiotropy
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U2 - 10.1073/pnas.1007431107
DO - 10.1073/pnas.1007431107
M3 - Article
C2 - 21078970
AN - SCOPUS:78650470891
SN - 0027-8424
VL - 107
SP - 21199
EP - 21204
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 49
ER -