@article{1f1e2c66b7664c7098b62bfe833463d1,
title = "Association of IFNλ4 rs12979860 polymorphism with the acquisition of HCV and HIV infections among people who inject drugs",
abstract = "We investigated the presence of a single-nucleotide polymorphism designated rs12979860 in the interferon λ4 (IFNλ4) gene among 345 people who inject drugs (PWID) and 495 blood donors to evaluate associations between the rs12979860 genotypes and human immunodeficiency virus/hepatitis C virus (HIV/HCV). The rs12979860 TT genotype was over-represented among HIV+ PWID than HIV− PWID and blood donors (16% vs 8% and 10%, P = 0.03, respectively). PWID with TT genotype had approximately twice the probability of being HIV+ (odds ratio [OR], 2.19; 95% confidence interval [CI], 1.11 to 4.33) than PWID without TT. Every additional year of intravenous drug use (IVDU) decreased the OR 1.16 times (OR, 0.86; 95% CI, 0.75 to 0.98). This suggests that rs12979860 TT increases susceptibility to HIV and this impact decreases with increasing duration of IVDU.",
keywords = "Hepatitis C Virus, Human Immunodeficiency Virus, IVDU, Interferons, human immune deficiency virus/hepatitis C virus coinfection, interferon λ, interleukin-28B",
author = "J{\~o}geda, {Ene Ly} and Radko Avi and Merit Pauskar and Eveli Kallas and T{\~o}nis Karki and {Des Jarlais}, Don and Anneli Uusk{\"u}la and Karolin Toompere and Irja Lutsar and Kristi Huik",
note = "Funding Information: We would like to thank all study participants, the teams from the nongovernmental organisation “Convictus,” and Kristina Marsh for coordinating the study. The work presented here was funded by the Basic Financing and the Target Financing of Estonian Ministry of Education and Research (PUT1580, IUT34‐24, and IUT34‐17), the European Union through the European Regional Development Fund, the Archimedes Foundation, and the National Institutes of Health (USA) grant R01DA003574. Funding Information: European Union Through The European Regional Development Fund, The Archimedes Foundation and the National Institutes of Health (USA), Grant/Award Number: R01DA003574; Basic Financing and The Target Financing of Estonian Ministry of Education and Research, Grant/ Award Numbers: PUT1580, IUT34‐24, IUT34‐17 Publisher Copyright: {\textcopyright} 2018 Wiley Periodicals, Inc.",
year = "2018",
month = nov,
doi = "10.1002/jmv.25258",
language = "English (US)",
volume = "90",
pages = "1779--1783",
journal = "Journal of Medical Virology",
issn = "0146-6615",
publisher = "Wiley-Liss Inc.",
number = "11",
}