Association of rigid-compulsive behavior with functional constipation in autism spectrum disorder

Sarah Marler; Bradley J. Ferguson; Evon Batey Lee; Brittany Peters; Kent C. Williams; Erin McDonnell; Eric A. Macklin; Pat Levitt; Kara Gross Margolis; David Q. Beversdorf; Jeremy Veenstra-VanderWeele

doi:10.1007/s10803-017-3084-6

Association of rigid-compulsive behavior with functional constipation in autism spectrum disorder

Sarah Marler, Bradley J. Ferguson, Evon Batey Lee, Brittany Peters, Kent C. Williams, Erin McDonnell, Eric A. Macklin, Pat Levitt, Kara Gross Margolis, David Q. Beversdorf, Jeremy Veenstra-VanderWeele

Molecular Pathobiology

Research output: Contribution to journal › Article › peer-review

Abstract

Based upon checklist data from the Autism Speaks Autism Treatment Network, we hypothesized that functional constipation (FC) would be associated with rigid-compulsive behavior in children with autism spectrum disorder (ASD). We used the Questionnaire on Pediatric Gastrointestinal Symptoms-Rome III to assess FC symptoms in 108 children with ASD. As hypothesized, FC was associated with parent ratings on the Repetitive Behavior Scales-Revised (RBS-R) Compulsive, Ritualistic, and Sameness subscales in the overall population. Of note, FC was less common in children who were not taking medications that target behavior or treat FC. In the medication-freechildren, rigid-compulsive behavior was not significantly associated with FC. More research is needed to understand the mechanisms underlying these associations.

Original language	English (US)
Pages (from-to)	1673-1681
Number of pages	9
Journal	Journal of Autism and Developmental Disorders
Volume	47
Issue number	6
DOIs	https://doi.org/10.1007/s10803-017-3084-6
State	Published - Jun 1 2017

Keywords

Developmental
Enteric
Gut
Medical comorbidity
Microbiome
Obsessive compulsive disorder
Serotonin

ASJC Scopus subject areas

Developmental and Educational Psychology

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10.1007/s10803-017-3084-6

Cite this

Marler, S., Ferguson, B. J., Lee, E. B., Peters, B., Williams, K. C., McDonnell, E., Macklin, E. A., Levitt, P., Margolis, K. G., Beversdorf, D. Q., & Veenstra-VanderWeele, J. (2017). Association of rigid-compulsive behavior with functional constipation in autism spectrum disorder. Journal of Autism and Developmental Disorders, 47(6), 1673-1681. https://doi.org/10.1007/s10803-017-3084-6

Marler, S, Ferguson, BJ, Lee, EB, Peters, B, Williams, KC, McDonnell, E, Macklin, EA, Levitt, P, Margolis, KG, Beversdorf, DQ & Veenstra-VanderWeele, J 2017, 'Association of rigid-compulsive behavior with functional constipation in autism spectrum disorder', Journal of Autism and Developmental Disorders, vol. 47, no. 6, pp. 1673-1681. https://doi.org/10.1007/s10803-017-3084-6

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abstract = "Based upon checklist data from the Autism Speaks Autism Treatment Network, we hypothesized that functional constipation (FC) would be associated with rigid-compulsive behavior in children with autism spectrum disorder (ASD). We used the Questionnaire on Pediatric Gastrointestinal Symptoms-Rome III to assess FC symptoms in 108 children with ASD. As hypothesized, FC was associated with parent ratings on the Repetitive Behavior Scales-Revised (RBS-R) Compulsive, Ritualistic, and Sameness subscales in the overall population. Of note, FC was less common in children who were not taking medications that target behavior or treat FC. In the medication-freechildren, rigid-compulsive behavior was not significantly associated with FC. More research is needed to understand the mechanisms underlying these associations.",

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doi = "10.1007/s10803-017-3084-6",

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AU - Lee, Evon Batey

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AU - Williams, Kent C.

AU - McDonnell, Erin

AU - Macklin, Eric A.

AU - Levitt, Pat

AU - Margolis, Kara Gross

AU - Beversdorf, David Q.

AU - Veenstra-VanderWeele, Jeremy

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N2 - Based upon checklist data from the Autism Speaks Autism Treatment Network, we hypothesized that functional constipation (FC) would be associated with rigid-compulsive behavior in children with autism spectrum disorder (ASD). We used the Questionnaire on Pediatric Gastrointestinal Symptoms-Rome III to assess FC symptoms in 108 children with ASD. As hypothesized, FC was associated with parent ratings on the Repetitive Behavior Scales-Revised (RBS-R) Compulsive, Ritualistic, and Sameness subscales in the overall population. Of note, FC was less common in children who were not taking medications that target behavior or treat FC. In the medication-freechildren, rigid-compulsive behavior was not significantly associated with FC. More research is needed to understand the mechanisms underlying these associations.

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Association of rigid-compulsive behavior with functional constipation in autism spectrum disorder

Abstract

Keywords

ASJC Scopus subject areas

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