@article{46252fb309cb44e595ac3b9ee6e3f1a0,
title = "Associations between cytokine gene variations and severe persistent breast pain in women following breast cancer surgery",
abstract = "Persistent pain following breast cancer surgery is a significant clinical problem. Although immune mechanisms may play a role in the development and maintenance of persistent pain, few studies have evaluated for associations between persistent breast pain following breast cancer surgery and variations in cytokine genes. In this study, associations between previously identified extreme persistent breast pain phenotypes (ie, no pain vs severe pain) and single nucleotide polymorphisms (SNPs) spanning 15 cytokine genes were evaluated. In unadjusted analyses, the frequency of 13 SNPs and 3 haplotypes in 7 genes differed significantly between the no pain and severe pain classes. After adjustment for preoperative breast pain and the severity of average postoperative pain, 1 SNP (ie, interleukin [IL] 1 receptor 2 rs11674595) and 1 haplotype (ie, IL10 haplotype A8) were associated with pain group membership. These findings suggest a role for cytokine gene polymorphisms in the development of persistent breast pain following breast cancer surgery. Perspective This study evaluated for associations between cytokine gene variations and the severity of persistent breast pain in women following breast cancer surgery. Variations in 2 cytokine genes were associated with severe breast pain. The results suggest that cytokines play a role in the development of persistent postsurgical pain.",
keywords = "Cytokines, breast cancer surgery, candidate genes, persistent pain, polymorphism",
author = "Kimberly Stephens and Cooper, {Bruce A.} and Claudia West and Paul, {Steven M.} and Baggott, {Christina R.} and Merriman, {John D.} and Anand Dhruva and Kober, {Kord M.} and Langford, {Dale J.} and Heather Leutwyler and Luce, {Judith A.} and Schmidt, {Brian L.} and Abrams, {Gary M.} and Charles Elboim and Deborah Hamolsky and Levine, {Jon D.} and Christine Miaskowski and Aouizerat, {Bradley E.}",
note = "Funding Information: This study was funded by grants from the National Cancer Institute ( CA107091 and CA118658 ). B.E.A. was funded through the National Institutes of Health (NIH) Roadmap for Medical Research Grant ( KL2 RR624130 ). K.S. was supported by an institutional training grant ( T32 NR07088 ) from the National Institute of Nursing Research and a Graduate Student Research Award and Century Club funds from the University of California San Francisco. J.D.M. was supported by a National Institute of Nursing Research F31 National Research Service Award (NR012604); an American Cancer Society (ACS) Doctoral Degree Scholarship in Cancer Nursing (DSCNR-10-087); an Oncology Nursing Society Foundation doctoral scholarship; and a University of California, San Francisco (UCSF), Nursing Alumni Association Scholarship. C.R.B. is supported by an ACS Mentored Research Scholar Grant ( MRSG-12-01-PCSM ). A.D. is funded through an NIH Mentored Patient-Oriented Research Career Development Award ( K23 AT005340 ). D.J.L. is supported by a Breast Cancer Research Program Department of Defense Postdoctoral Fellowship. H.L. is supported by the National Center for Advancing Translational Sciences , National Institutes of Health, through UCSF-CTSI Grant KL2TR000143. C.M. is an American Cancer Society Clinical Research Professor. This project is supported by NIH/National Center for Research Resources UCSF-CTSI Grant Number UL1 RR024131. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH. ",
year = "2014",
month = feb,
doi = "10.1016/j.jpain.2013.09.015",
language = "English (US)",
volume = "15",
pages = "169--180",
journal = "Journal of Pain",
issn = "1526-5900",
publisher = "Elsevier B.V.",
number = "2",
}