Associations of MHC genes with levels of caries-inducing organisms and caries severity in African-American women

Ronald T. Acton, Ananda P. Dasanayake, Renee A. Harrison, Yihong Li, Jeffrey M. Roseman, Rodney C.P. Go, Howard Wiener, Page W. Caufield

Research output: Contribution to journalArticle

Abstract

The aim of this investigation was to evaluate the relationship between MHC alleles at the HLA-DRB1, DQB1 and TNFa microsatellite loci and levels of oral bacteria that play a role in the etiology of dental caries, and the DMFS index in 186 AA primparous women. The average age of the cohort was 20.8 ± 3.7 years. The median DMFS index was 9 (range 0-68). High levels of S. mutans were positively associated with DRB1*3 and DRB1*4 presence (p ≤ 0.005). DRB1*8 was positively associated with higher levels of S. mutans as a percentage of total Streptococci (p = 0.04). DRB1*1 was positively associated with high levels L. casei (p = 0.04). DQB1 alleles were not observed associated with oral bacterial levels. TNFa allele 103 was negatively associated (p = 0.04), and TNFa 117 was positively associated (p = 0.007), with high levels of L. acidophilus. No significant associations were observed between any DRB1, DQB1 or TNFa allele and the DMFS index. These results support an hypothesis of an association between host HLA class II and TNFa genetic profile and colonization of S. mutans, L. casei, and L. acidophilus thought to be pathogens involved in the etiology of dental caries.

Original languageEnglish (US)
Pages (from-to)984-989
Number of pages6
JournalHuman Immunology
Volume60
Issue number10
DOIs
StatePublished - 1999

Keywords

  • African-Americans
  • Caries
  • HLA
  • TNFα

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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