Astrocytic β2- Adrenergic receptors mediate hippocampal long- Term memory consolidation

Virginia Gao, Akinobu Suzuki, Pierre J. Magistretti, Sylvain Lengacher, Gabriella Pollonini, Michael Q. Steinman, Cristina M. Alberini

Research output: Contribution to journalArticlepeer-review


Emotionally relevant experiences form strong and long-lasting memories by critically engaging the stress hormone/neurotransmitter noradrenaline, which mediates and modulates the consolidation of these memories. Noradrenaline acts through adrenergic receptors (ARs), of which β2- Adrenergic receptors (βARs) are of particular importance. The differential anatomical and cellular distribution of βAR subtypes in the brain suggests that they play distinct roles in memory processing, although much about their specific contributions and mechanisms of action remains to be understood. Here we show that astrocytic rather than neuronal β2ARs in the hippocampus play a key role in the consolidation of a fear-based contextual memory. These hippocampal β2ARs, but not β1ARs, are coupled to the training-dependent release of lactate from astrocytes, which is necessary for long- Term memory formation and for underlying molecular changes. This key metabolic role of astrocytic β2ARs may represent a novel target mechanism for stress-related psychopathologies and neurodegeneration.

Original languageEnglish (US)
Pages (from-to)8526-8531
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number30
StatePublished - Jul 26 2016


  • Astrocyte
  • Hippocampus
  • Lactate
  • Memory
  • β- Adrenergic receptor

ASJC Scopus subject areas

  • General


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