Astroglial 5-HT1a receptors and S-100 beta in development and plasticity

P. M. Whitaker-Azmitia; E. C. Azmitia

Astroglial 5-HT1a receptors and S-100 beta in development and plasticity

P. M. Whitaker-Azmitia, E. C. Azmitia

Biology and Genomics

Research output: Contribution to journal › Article › peer-review

Abstract

The work described in this article is concerned with the role of the 5-HT1a receptor in mediating the neurotrophic effects of serotonin, principally through the release of the substance S-100 beta from astroglial cells. These receptors are also present in astrocytes of the mature brain and may play a role in the synaptic plasticity necessary for certain experience-driven brain changes, such as memory or learning. The presence of these receptors on astroglial cells of the adult brain also has interesting implications for the mechanism of action of many psychotropic drugs acting through the serotonergic system.

Original language	Undefined
Pages (from-to)	233-8
Journal	Perspectives in Developmental Neurobiology
Volume	2
Issue number	3
State	Published - 1994

Keywords

Aging/*physiology Animals Astrocytes/*physiology Brain/growth & development/*physiology Calcium-Binding Proteins/*physiology Humans Mammals Nerve Growth Factors *Neuronal Plasticity Psychotropic Drugs/pharmacology Receptors, Serotonin/drug effects/*physiology Receptors, Serotonin, 5-HT1 S100 Calcium Binding Protein beta Subunit S100 Proteins/*physiology Serotonin/*physiology

Cite this

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title = "Astroglial 5-HT1a receptors and S-100 beta in development and plasticity",

abstract = "The work described in this article is concerned with the role of the 5-HT1a receptor in mediating the neurotrophic effects of serotonin, principally through the release of the substance S-100 beta from astroglial cells. These receptors are also present in astrocytes of the mature brain and may play a role in the synaptic plasticity necessary for certain experience-driven brain changes, such as memory or learning. The presence of these receptors on astroglial cells of the adult brain also has interesting implications for the mechanism of action of many psychotropic drugs acting through the serotonergic system.",

keywords = "Aging/*physiology Animals Astrocytes/*physiology Brain/growth & development/*physiology Calcium-Binding Proteins/*physiology Humans Mammals Nerve Growth Factors *Neuronal Plasticity Psychotropic Drugs/pharmacology Receptors, Serotonin/drug effects/*physiology Receptors, Serotonin, 5-HT1 S100 Calcium Binding Protein beta Subunit S100 Proteins/*physiology Serotonin/*physiology",

author = "Whitaker-Azmitia, {P. M.} and Azmitia, {E. C.}",

note = "Whitaker-Azmitia, P M Azmitia, E C Journal Article Research Support, U.S. Gov't, P.H.S. Review United states Perspect Dev Neurobiol. 1994;2(3):233-8.",

year = "1994",

language = "Undefined",

volume = "2",

pages = "233--8",

journal = "Perspectives in Developmental Neurobiology",

issn = "1064-0517",

publisher = "Gordon and Breach Science Publishers",

number = "3",

}

TY - JOUR

T1 - Astroglial 5-HT1a receptors and S-100 beta in development and plasticity

AU - Whitaker-Azmitia, P. M.

AU - Azmitia, E. C.

N1 - Whitaker-Azmitia, P M Azmitia, E C Journal Article Research Support, U.S. Gov't, P.H.S. Review United states Perspect Dev Neurobiol. 1994;2(3):233-8.

PY - 1994

Y1 - 1994

N2 - The work described in this article is concerned with the role of the 5-HT1a receptor in mediating the neurotrophic effects of serotonin, principally through the release of the substance S-100 beta from astroglial cells. These receptors are also present in astrocytes of the mature brain and may play a role in the synaptic plasticity necessary for certain experience-driven brain changes, such as memory or learning. The presence of these receptors on astroglial cells of the adult brain also has interesting implications for the mechanism of action of many psychotropic drugs acting through the serotonergic system.

AB - The work described in this article is concerned with the role of the 5-HT1a receptor in mediating the neurotrophic effects of serotonin, principally through the release of the substance S-100 beta from astroglial cells. These receptors are also present in astrocytes of the mature brain and may play a role in the synaptic plasticity necessary for certain experience-driven brain changes, such as memory or learning. The presence of these receptors on astroglial cells of the adult brain also has interesting implications for the mechanism of action of many psychotropic drugs acting through the serotonergic system.

KW - Aging/physiology Animals Astrocytes/physiology Brain/growth & development/physiology Calcium-Binding Proteins/physiology Humans Mammals Nerve Growth Factors Neuronal Plasticity Psychotropic Drugs/pharmacology Receptors, Serotonin/drug effects/physiology R

M3 - Article

SN - 1064-0517

VL - 2

SP - 233

EP - 238

JO - Perspectives in Developmental Neurobiology

JF - Perspectives in Developmental Neurobiology

IS - 3

ER -