Asymmetric Notch Amplification to Secure Stem Cell Identity

Anthony M. Rossi; Claude Desplan

doi:10.1016/j.devcel.2017.03.010

Asymmetric Notch Amplification to Secure Stem Cell Identity

Research output: Contribution to journal › Short survey › peer-review

Abstract

Stem cells self-renew and produce progenitors with limited proliferative potential. Reporting in Developmental Cell, Liu et al. (2017) demonstrate that in some neural stem cells, Notch activity is asymmetrically amplified by a positive feedback loop with the super elongation complex (SEC) to quickly differentiate between stem cells and progenitors.

Original language	English (US)
Pages (from-to)	513-514
Number of pages	2
Journal	Developmental Cell
Volume	40
Issue number	6
DOIs	https://doi.org/10.1016/j.devcel.2017.03.010
State	Published - Mar 27 2017

ASJC Scopus subject areas

Molecular Biology
General Biochemistry, Genetics and Molecular Biology
Developmental Biology
Cell Biology

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10.1016/j.devcel.2017.03.010

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title = "Asymmetric Notch Amplification to Secure Stem Cell Identity",

abstract = "Stem cells self-renew and produce progenitors with limited proliferative potential. Reporting in Developmental Cell, Liu et al. (2017) demonstrate that in some neural stem cells, Notch activity is asymmetrically amplified by a positive feedback loop with the super elongation complex (SEC) to quickly differentiate between stem cells and progenitors.",

author = "Rossi, {Anthony M.} and Claude Desplan",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Inc.",

year = "2017",

month = mar,

day = "27",

doi = "10.1016/j.devcel.2017.03.010",

language = "English (US)",

volume = "40",

pages = "513--514",

journal = "Developmental Cell",

issn = "1534-5807",

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T1 - Asymmetric Notch Amplification to Secure Stem Cell Identity

AU - Rossi, Anthony M.

AU - Desplan, Claude

PY - 2017/3/27

Y1 - 2017/3/27

N2 - Stem cells self-renew and produce progenitors with limited proliferative potential. Reporting in Developmental Cell, Liu et al. (2017) demonstrate that in some neural stem cells, Notch activity is asymmetrically amplified by a positive feedback loop with the super elongation complex (SEC) to quickly differentiate between stem cells and progenitors.

AB - Stem cells self-renew and produce progenitors with limited proliferative potential. Reporting in Developmental Cell, Liu et al. (2017) demonstrate that in some neural stem cells, Notch activity is asymmetrically amplified by a positive feedback loop with the super elongation complex (SEC) to quickly differentiate between stem cells and progenitors.

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U2 - 10.1016/j.devcel.2017.03.010

DO - 10.1016/j.devcel.2017.03.010

M3 - Short survey

C2 - 28350981

AN - SCOPUS:85016453328

SN - 1534-5807

VL - 40

SP - 513

EP - 514

JO - Developmental Cell

JF - Developmental Cell

IS - 6

ER -

Asymmetric Notch Amplification to Secure Stem Cell Identity

Abstract

ASJC Scopus subject areas

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