Asymmetric Notch Amplification to Secure Stem Cell Identity

Anthony M. Rossi, Claude Desplan

Research output: Contribution to journalShort survey

Abstract

Stem cells self-renew and produce progenitors with limited proliferative potential. Reporting in Developmental Cell, Liu et al. (2017) demonstrate that in some neural stem cells, Notch activity is asymmetrically amplified by a positive feedback loop with the super elongation complex (SEC) to quickly differentiate between stem cells and progenitors.

Original languageEnglish (US)
Pages (from-to)513-514
Number of pages2
JournalDevelopmental Cell
Volume40
Issue number6
DOIs
StatePublished - Mar 27 2017

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

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