TY - JOUR
T1 - At the Crossroads of Chemistry, Biology, and Materials
T2 - Structural DNA Nanotechnology
AU - Seeman, Nadrian C.
N1 - Funding Information:
I am grateful to all of my students, postdoctoral colleagues, and collaborators for their contributions to the founding of structural DNA nanotechnology. This research has been supported by grants GM-29554 from the National Institute of General Medical Sciences; N00014-98-1-0093 from the Office of Naval Research; DMI-0210844, EIA-0086015, DMR-01138790, and CTS-0103002 from the National Science Foundation; and F30602-01-2-0561 from the Defense Advanced Research Projects Agency/Air Force Office of Scientific Research.
PY - 2003/12
Y1 - 2003/12
N2 - Structural DNA nanotechnology consists of combining unusual DNA motifs by specific structurally well-defined cohesive interactions (primarily sticky ends) to produce target materials with predictable 3D structures. This effort has generated DNA polyhedral catenanes, robust nanomechanical devices, and a variety of periodic arrays in two dimensions. The system has been used to produce specific patterns on the mesoscale through designing and combining specific DNA strands, which are then examined by atomic force microscopy. The combination of these constructions with other chemical components is expected to contribute to the development of nanoelectronics, nanorobotics, and smart materials. The organizational capabilities of structural DNA nanotechnology are just beginning to be explored, and the field is expected ultimately to be able to organize a variety of species that will lead to exciting and possibly revolutionary materials.
AB - Structural DNA nanotechnology consists of combining unusual DNA motifs by specific structurally well-defined cohesive interactions (primarily sticky ends) to produce target materials with predictable 3D structures. This effort has generated DNA polyhedral catenanes, robust nanomechanical devices, and a variety of periodic arrays in two dimensions. The system has been used to produce specific patterns on the mesoscale through designing and combining specific DNA strands, which are then examined by atomic force microscopy. The combination of these constructions with other chemical components is expected to contribute to the development of nanoelectronics, nanorobotics, and smart materials. The organizational capabilities of structural DNA nanotechnology are just beginning to be explored, and the field is expected ultimately to be able to organize a variety of species that will lead to exciting and possibly revolutionary materials.
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U2 - 10.1016/j.chembiol.2003.12.002
DO - 10.1016/j.chembiol.2003.12.002
M3 - Review article
C2 - 14700623
AN - SCOPUS:0346338110
SN - 1074-5521
VL - 10
SP - 1151
EP - 1159
JO - Chemistry and Biology
JF - Chemistry and Biology
IS - 12
ER -