TY - GEN
T1 - Atomic force microscopy for single cell analysis and mechanophenotyping of circulating tumor cells
AU - Glia, Ayoub
AU - Deliorman, Muhammedin
AU - Qasaimeh, Mohammad A.
N1 - Funding Information:
ACKNOWLEDGMENTS We acknowledge the funding from the NYUAD 2017 Research Enhancement Fund, NYUAD, UAE, and the Terry Fox Foundation’s International Run Program, Vancouver, Canada. We acknowledge the technical support from NYUAD Core Technology Platforms. A.G. acknowledges the NYUAD Global PhD Fellowship. M.A.Q acknowledges financial support from NYUAD.
Publisher Copyright:
© 2020 IEEE.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2020/7/13
Y1 - 2020/7/13
N2 - Circulating tumor cells (CTCs) are attracting increasing interest in medical sciences as they play a key role to understanding cancer metastasis. The possibility to phenotype CTCs based on their physiological nature, biological responses, and defense mechanisms could open new venues for precision diagnosis, personalized treatments, and preventative measures. In this work, we employed Atomic Force Microscopy (AFM) for mechanophenotyping clinical prostate CTCs based on their measured elastic and adhesive properties. We performed the AFM force measurements on different cancer cell lines, namely MCF7 cells (breast cancer), LNCaP and PC3 cells (prostate cancer), and compared the results with clinical CTCs isolated from blood of prostate cancer patients.
AB - Circulating tumor cells (CTCs) are attracting increasing interest in medical sciences as they play a key role to understanding cancer metastasis. The possibility to phenotype CTCs based on their physiological nature, biological responses, and defense mechanisms could open new venues for precision diagnosis, personalized treatments, and preventative measures. In this work, we employed Atomic Force Microscopy (AFM) for mechanophenotyping clinical prostate CTCs based on their measured elastic and adhesive properties. We performed the AFM force measurements on different cancer cell lines, namely MCF7 cells (breast cancer), LNCaP and PC3 cells (prostate cancer), and compared the results with clinical CTCs isolated from blood of prostate cancer patients.
KW - AFM
KW - CTCs
KW - CellAdhesion
KW - Diagnostics
KW - Liquid Biopsy
KW - Microfluidics
KW - Phenotyping
KW - Prostate
KW - Viscoelasticity
UR - http://www.scopus.com/inward/record.url?scp=85099577862&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85099577862&partnerID=8YFLogxK
U2 - 10.1109/MARSS49294.2020.9307848
DO - 10.1109/MARSS49294.2020.9307848
M3 - Conference contribution
AN - SCOPUS:85099577862
T3 - Proceedings of MARSS 2020: International Conference on Manipulation, Automation, and Robotics at Small Scales
BT - Proceedings of MARSS 2020
A2 - Haliyo, Sinan
A2 - Boudaoud, Mokrane
A2 - Sill, Albert
A2 - Fatikow, Sergej
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2020 International Conference on Manipulation, Automation, and Robotics at Small Scales, MARSS 2020
Y2 - 13 July 2020 through 17 July 2020
ER -