Atomic structure of a short α-helix stabilized by a main chain hydrogen-bond surrogate

Jie Liu, Deyun Wang, Qi Zheng, Min Lu, Paramjit S. Arora

Research output: Contribution to journalArticle

Abstract

Herein we report the 1.15 Å X-ray crystal structure of a short α-helix in which the N-terminal i and i + 4 main chain hydrogen bond is replaced with a carbon-carbon bond. The structure shows that the hydrogen-bond surrogate (HBS) derived α-helix truly resembles the structure of canonical α-helices and provides unequivocal support for our helix nucleation strategy.

Original languageEnglish (US)
Pages (from-to)4334-4337
Number of pages4
JournalJournal of the American Chemical Society
Volume130
Issue number13
DOIs
StatePublished - Apr 2 2008

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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