Atomic structure of a short α-helix stabilized by a main chain hydrogen-bond surrogate

Jie Liu; Deyun Wang; Qi Zheng; Min Lu; Paramjit S. Arora

doi:10.1021/ja077704u

Atomic structure of a short α-helix stabilized by a main chain hydrogen-bond surrogate

Jie Liu, Deyun Wang, Qi Zheng, Min Lu, Paramjit S. Arora

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Herein we report the 1.15 Å X-ray crystal structure of a short α-helix in which the N-terminal i and i + 4 main chain hydrogen bond is replaced with a carbon-carbon bond. The structure shows that the hydrogen-bond surrogate (HBS) derived α-helix truly resembles the structure of canonical α-helices and provides unequivocal support for our helix nucleation strategy.

Original language	English (US)
Pages (from-to)	4334-4337
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	130
Issue number	13
DOIs	https://doi.org/10.1021/ja077704u
State	Published - Apr 2 2008

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja077704u

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abstract = "Herein we report the 1.15 {\AA} X-ray crystal structure of a short α-helix in which the N-terminal i and i + 4 main chain hydrogen bond is replaced with a carbon-carbon bond. The structure shows that the hydrogen-bond surrogate (HBS) derived α-helix truly resembles the structure of canonical α-helices and provides unequivocal support for our helix nucleation strategy.",

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AU - Wang, Deyun

AU - Zheng, Qi

AU - Lu, Min

AU - Arora, Paramjit S.

PY - 2008/4/2

Y1 - 2008/4/2

N2 - Herein we report the 1.15 Å X-ray crystal structure of a short α-helix in which the N-terminal i and i + 4 main chain hydrogen bond is replaced with a carbon-carbon bond. The structure shows that the hydrogen-bond surrogate (HBS) derived α-helix truly resembles the structure of canonical α-helices and provides unequivocal support for our helix nucleation strategy.

AB - Herein we report the 1.15 Å X-ray crystal structure of a short α-helix in which the N-terminal i and i + 4 main chain hydrogen bond is replaced with a carbon-carbon bond. The structure shows that the hydrogen-bond surrogate (HBS) derived α-helix truly resembles the structure of canonical α-helices and provides unequivocal support for our helix nucleation strategy.

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Atomic structure of a short α-helix stabilized by a main chain hydrogen-bond surrogate

Abstract

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