Attacks and Countermeasures for Digital Microfluidic Biochips: Extended Abstract

Navajit Singh Baban; Prithwish Basu Roy; Pauline John; Azhar Zam; Sukanta Bhattacharjee; Young-Ak (Rafael) Song; Ramesh Karri; Krishnendu Chakrabarty

doi:10.1007/978-3-031-80408-3_1

Attacks and Countermeasures for Digital Microfluidic Biochips: Extended Abstract

Navajit Singh Baban, Prithwish Basu Roy, Pauline John, Azhar Zam, Sukanta Bhattacharjee, Young-Ak (Rafael) Song, Ramesh Karri, Krishnendu Chakrabarty

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Digital Microfluidic Biochips (DMFBs) precisely control droplets on an electrode array, making them vital for healthcare. However, they are vulnerable to numerous security threats, including structural modifications during the design phase, material vulnerabilities in manufacturing, and code-level cyber-physical attacks. These risks encompass microstructural changes, chemical tampering, and manipulation of bioprotocols. This study experimentally demonstrates these attacks on a commercial DMFB and proposes using the optical coherence tomography (OCT) technique as a countermeasure to detect structural and material anomalies, along with hash-based techniques for code-level defense.

Original language	English (US)
Title of host publication	Security, Privacy, and Applied Cryptography Engineering - 14th International Conference, SPACE 2024, Proceedings
Editors	Johann Knechtel, Urbi Chatterjee, Domenic Forte
Publisher	Springer Science and Business Media Deutschland GmbH
Pages	1-5
Number of pages	5
ISBN (Print)	9783031804076
DOIs	https://doi.org/10.1007/978-3-031-80408-3_1
State	Published - 2025
Event	14th International Conference on Security, Privacy and Applied Cryptographic Engineering, SPACE 2024 - Kottayam, India Duration: Dec 14 2024 → Dec 17 2024

Publication series

Name	Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume	15351 LNCS
ISSN (Print)	0302-9743
ISSN (Electronic)	1611-3349

Conference

Conference	14th International Conference on Security, Privacy and Applied Cryptographic Engineering, SPACE 2024
Country/Territory	India
City	Kottayam
Period	12/14/24 → 12/17/24

Keywords

Cyber-physical Security
Digital Microfluidic Biochips
Droplet
Hash
Optical Coherence Tomography
Plasma

ASJC Scopus subject areas

Theoretical Computer Science
General Computer Science

Access to Document

10.1007/978-3-031-80408-3_1

Cite this

Baban, N. S., Roy, P. B., John, P., Zam, A., Bhattacharjee, S., Song, Y.-A., Karri, R., & Chakrabarty, K. (2025). Attacks and Countermeasures for Digital Microfluidic Biochips: Extended Abstract. In J. Knechtel, U. Chatterjee, & D. Forte (Eds.), Security, Privacy, and Applied Cryptography Engineering - 14th International Conference, SPACE 2024, Proceedings (pp. 1-5). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 15351 LNCS). Springer Science and Business Media Deutschland GmbH. https://doi.org/10.1007/978-3-031-80408-3_1

Attacks and Countermeasures for Digital Microfluidic Biochips: Extended Abstract. / Baban, Navajit Singh; Roy, Prithwish Basu; John, Pauline et al.
Security, Privacy, and Applied Cryptography Engineering - 14th International Conference, SPACE 2024, Proceedings. ed. / Johann Knechtel; Urbi Chatterjee; Domenic Forte. Springer Science and Business Media Deutschland GmbH, 2025. p. 1-5 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 15351 LNCS).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Baban, NS, Roy, PB, John, P, Zam, A, Bhattacharjee, S, Song, Y-A , Karri, R & Chakrabarty, K 2025, Attacks and Countermeasures for Digital Microfluidic Biochips: Extended Abstract. in J Knechtel, U Chatterjee & D Forte (eds), Security, Privacy, and Applied Cryptography Engineering - 14th International Conference, SPACE 2024, Proceedings. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 15351 LNCS, Springer Science and Business Media Deutschland GmbH, pp. 1-5, 14th International Conference on Security, Privacy and Applied Cryptographic Engineering, SPACE 2024, Kottayam, India, 12/14/24. https://doi.org/10.1007/978-3-031-80408-3_1

Baban NS, Roy PB, John P, Zam A, Bhattacharjee S, Song YA et al. Attacks and Countermeasures for Digital Microfluidic Biochips: Extended Abstract. In Knechtel J, Chatterjee U, Forte D, editors, Security, Privacy, and Applied Cryptography Engineering - 14th International Conference, SPACE 2024, Proceedings. Springer Science and Business Media Deutschland GmbH. 2025. p. 1-5. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)). doi: 10.1007/978-3-031-80408-3_1

Baban, Navajit Singh ; Roy, Prithwish Basu ; John, Pauline et al. / Attacks and Countermeasures for Digital Microfluidic Biochips : Extended Abstract. Security, Privacy, and Applied Cryptography Engineering - 14th International Conference, SPACE 2024, Proceedings. editor / Johann Knechtel ; Urbi Chatterjee ; Domenic Forte. Springer Science and Business Media Deutschland GmbH, 2025. pp. 1-5 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)).

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