TY - JOUR
T1 - Auditory processing remains sensitive to environmental experience during adolescence in a rodent model
AU - Anbuhl, Kelsey L.
AU - Yao, Justin D.
AU - Hotz, Robert A.
AU - Mowery, Todd M.
AU - Sanes, Dan H.
N1 - Funding Information:
This work was supported by NIMH T32-MH019524 (K.L.A.), NIDCD F32-DC018195-02 (K.L.A.), and NIDCD R01-DC011284 (D.H.S.). We would also like to acknowledge the Endocrine Technologies Core (ETSC) at the Oregon National Primate Research Center (ONPRC), which is supported by NIH Grant P51 OD011092 (ONPRC). Research reported in this publication through ETSC at the ONPRC was supported by the Office of the Director, National Institutes of Health of the National Institutes of Health under Award Number S10OD026701. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. We also thank Lisa Ramirez for assistance in histological preparation and analyses. We are grateful to Melissa Caras and members of the Sanes lab for support and insightful feedback regarding analyses and interpretation of the data.
Funding Information:
This work was supported by NIMH T32-MH019524 (K.L.A.), NIDCD F32-DC018195-02 (K.L.A.), and NIDCD R01-DC011284 (D.H.S.). We would also like to acknowledge the Endocrine Technologies Core (ETSC) at the Oregon National Primate Research Center (ONPRC), which is supported by NIH Grant P51 OD011092 (ONPRC). Research reported in this publication through ETSC at the ONPRC was supported by the Office of the Director, National Institutes of Health of the National Institutes of Health under Award Number S10OD026701. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. We also thank Lisa Ramirez for assistance in histological preparation and analyses. We are grateful to Melissa Caras and members of the Sanes lab for support and insightful feedback regarding analyses and interpretation of the data.
Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - Elevated neural plasticity during development contributes to dramatic improvements in perceptual, motor, and cognitive skills. However, malleable neural circuits are vulnerable to environmental influences that may disrupt behavioral maturation. While these risks are well-established prior to sexual maturity (i.e., critical periods), the degree of neural vulnerability during adolescence remains uncertain. Here, we induce transient hearing loss (HL) spanning adolescence in gerbils, and ask whether behavioral and neural maturation are disrupted. We find that adolescent HL causes a significant perceptual deficit that can be attributed to degraded auditory cortex processing, as assessed with wireless single neuron recordings and within-session population-level analyses. Finally, auditory cortex brain slices from adolescent HL animals reveal synaptic deficits that are distinct from those typically observed after critical period deprivation. Taken together, these results show that diminished adolescent sensory experience can cause long-lasting behavioral deficits that originate, in part, from a dysfunctional cortical circuit.
AB - Elevated neural plasticity during development contributes to dramatic improvements in perceptual, motor, and cognitive skills. However, malleable neural circuits are vulnerable to environmental influences that may disrupt behavioral maturation. While these risks are well-established prior to sexual maturity (i.e., critical periods), the degree of neural vulnerability during adolescence remains uncertain. Here, we induce transient hearing loss (HL) spanning adolescence in gerbils, and ask whether behavioral and neural maturation are disrupted. We find that adolescent HL causes a significant perceptual deficit that can be attributed to degraded auditory cortex processing, as assessed with wireless single neuron recordings and within-session population-level analyses. Finally, auditory cortex brain slices from adolescent HL animals reveal synaptic deficits that are distinct from those typically observed after critical period deprivation. Taken together, these results show that diminished adolescent sensory experience can cause long-lasting behavioral deficits that originate, in part, from a dysfunctional cortical circuit.
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U2 - 10.1038/s41467-022-30455-9
DO - 10.1038/s41467-022-30455-9
M3 - Article
C2 - 35610222
AN - SCOPUS:85130733527
SN - 2041-1723
VL - 13
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 2872
ER -