TY - JOUR
T1 - Author Correction
T2 - Testing the key assumption of heritability estimates based on genome-wide genetic relatedness (Journal of Human Genetics, (2014), 59, 6, (342-345), 10.1038/jhg.2014.14)
AU - Conley, Dalton
AU - Siegal, Mark L.
AU - Domingue, Benjamin W.
AU - Harris, Kathleen Mullan
AU - McQueen, Matthew B.
AU - Boardman, Jason D.
N1 - Publisher Copyright:
© 2019, The Author(s), under exclusive licence to The Japan Society of Human Genetics.
PY - 2019/6/1
Y1 - 2019/6/1
N2 - In the original paper, we used the variable “URBRUR08,” from the 2008 survey wave as a measure of childhood urbanicity. Upon further investigation we realized that this variable actually measured Beale urban-rural code during the respondent’s adulthood. Thus, we reran our analysis of the pseudo-heritability of childhood urbanicity using the variable. The original results hold such that even with the first 20 principal components held constant, childhood urban-rural status appears to be ~20% “heritable” in GREML models—a figure that is actually higher than the original estimate reported in the paper (14% controlling for 25 PCs, 15% controlling for 10 PCs, and 29% controlling for two PCs). Meanwhile, the heritabilities of the other phenotypes—height, BMI and education—still do not change when they are residualized on childhood urbanicity. In other words, the original results of the paper do not change.
AB - In the original paper, we used the variable “URBRUR08,” from the 2008 survey wave as a measure of childhood urbanicity. Upon further investigation we realized that this variable actually measured Beale urban-rural code during the respondent’s adulthood. Thus, we reran our analysis of the pseudo-heritability of childhood urbanicity using the variable. The original results hold such that even with the first 20 principal components held constant, childhood urban-rural status appears to be ~20% “heritable” in GREML models—a figure that is actually higher than the original estimate reported in the paper (14% controlling for 25 PCs, 15% controlling for 10 PCs, and 29% controlling for two PCs). Meanwhile, the heritabilities of the other phenotypes—height, BMI and education—still do not change when they are residualized on childhood urbanicity. In other words, the original results of the paper do not change.
UR - http://www.scopus.com/inward/record.url?scp=85063748709&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85063748709&partnerID=8YFLogxK
U2 - 10.1038/s10038-019-0593-5
DO - 10.1038/s10038-019-0593-5
M3 - Comment/debate
C2 - 30940889
AN - SCOPUS:85063748709
SN - 1434-5161
VL - 64
SP - 597
EP - 598
JO - Journal of Human Genetics
JF - Journal of Human Genetics
IS - 6
ER -