Automated volumetric evaluation of stereoscopic disc photography

Juan Xu, Hiroshi Ishikawa, Gadi Wollstein, Richard A. Bilonick, Larry Kagemann, Jamie E. Craig, David A. Mackey, Alex W. Hewitt, Joel S. Schuman

Research output: Contribution to journalArticlepeer-review


PURPOSE: To develop a fully automated algorithm (AP) to perform a volumetric measure of the optic disc using conventional stereoscopic optic nerve head (ONH) photographs, and to compare algorithm-produced parameters with manual photogrammetry (MP), scanning laser ophthalmoscope (SLO) and optical coherence tomography (OCT) measurements. METHODS: One hundred twenty-two stereoscopic optic disc photographs (61 subjects) were analyzed. Disc area, rim area, cup area, cup/disc area ratio, vertical cup/disc ratio, rim volume and cup volume were automatically computed by the algorithm. Latent variable measurement error models were used to assess measurement reproducibility for the four techniques. RESULTS: AP had better reproducibility for disc area and cup volume and worse reproducibility for cup/disc area ratio and vertical cup/disc ratio, when the measurements were compared to the MP, SLO and OCT methods. CONCLUSION: AP provides a useful technique for an objective quantitative assessment of 3D ONH structures.

Original languageEnglish (US)
Pages (from-to)11347-11359
Number of pages13
JournalOptics Express
Issue number11
StatePublished - May 24 2010

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics


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