Backscattering Mueller Matrix Analysis for Biomedical Optical Diagnostics

Andreas H. Hielscher; Angelia A. Eick; Judith R. Mourant; D. Chen; James P. Freyer; Irving J. Bigio

Backscattering Mueller Matrix Analysis for Biomedical Optical Diagnostics

Andreas H. Hielscher, Angelia A. Eick, Judith R. Mourant, D. Chen, James P. Freyer, Irving J. Bigio

Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We report on the development of a method that records spatially dependent intensity patterns of polarized light that is diffusely backscattered from highly scattering media. It is demonstrated that these intensity patterns can be used to differentiate turbid media, such as polystyrene-sphere and biological-cell suspensions. Our technique employs polarized light from a He-Ne laser, which is focused onto the surface of the scattering medium. A surface area of approximately 4×4 cm centered on the light input point is imaged through polarization-analysis optics onto a CCD camera. One can observe a large variety of intensity patterns by varying the polarization state of the incident laser light and changing the analyzer configuration to detect different polarization components of the backscattered light. Introducing the Mueller-matrix concept for diffusely backscattered light, a framework is provided to select a subset of measurements that comprehensively describe the optical properties of backscattering media.

Original language	English (US)
Title of host publication	Biomedical Optical Spectroscopy and Diagnostics, BOSD 1998
Publisher	Optica Publishing Group (formerly OSA)
Pages	20-25
Number of pages	6
ISBN (Electronic)	1557525471
State	Published - 1998
Event	Biomedical Optical Spectroscopy and Diagnostics, BOSD 1998 - Orlando, United States Duration: Mar 8 1998 → …

Publication series

Name	Optics InfoBase Conference Papers
ISSN (Electronic)	2162-2701

Conference

Conference	Biomedical Optical Spectroscopy and Diagnostics, BOSD 1998
Country/Territory	United States
City	Orlando
Period	3/8/98 → …

Keywords

Backscattering
Cell analysis
Multiple scattering;
Polarization

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Mechanics of Materials

Cite this

Backscattering Mueller Matrix Analysis for Biomedical Optical Diagnostics. / Hielscher, Andreas H.; Eick, Angelia A.; Mourant, Judith R. et al.
Biomedical Optical Spectroscopy and Diagnostics, BOSD 1998. Optica Publishing Group (formerly OSA), 1998. p. 20-25 (Optics InfoBase Conference Papers).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Hielscher, AH, Eick, AA, Mourant, JR, Chen, D, Freyer, JP & Bigio, IJ 1998, Backscattering Mueller Matrix Analysis for Biomedical Optical Diagnostics. in Biomedical Optical Spectroscopy and Diagnostics, BOSD 1998. Optics InfoBase Conference Papers, Optica Publishing Group (formerly OSA), pp. 20-25, Biomedical Optical Spectroscopy and Diagnostics, BOSD 1998, Orlando, United States, 3/8/98.

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title = "Backscattering Mueller Matrix Analysis for Biomedical Optical Diagnostics",

abstract = "We report on the development of a method that records spatially dependent intensity patterns of polarized light that is diffusely backscattered from highly scattering media. It is demonstrated that these intensity patterns can be used to differentiate turbid media, such as polystyrene-sphere and biological-cell suspensions. Our technique employs polarized light from a He-Ne laser, which is focused onto the surface of the scattering medium. A surface area of approximately 4×4 cm centered on the light input point is imaged through polarization-analysis optics onto a CCD camera. One can observe a large variety of intensity patterns by varying the polarization state of the incident laser light and changing the analyzer configuration to detect different polarization components of the backscattered light. Introducing the Mueller-matrix concept for diffusely backscattered light, a framework is provided to select a subset of measurements that comprehensively describe the optical properties of backscattering media.",

keywords = "Backscattering, Cell analysis, Multiple scattering;, Polarization",

author = "Hielscher, {Andreas H.} and Eick, {Angelia A.} and Mourant, {Judith R.} and D. Chen and Freyer, {James P.} and Bigio, {Irving J.}",

note = "Funding Information: This work was supported in part by a grant from the National Institutes of Health (CA71898), a fellowship from the Director's Office at Los Alamos National Laboratory, and funds from the Science and Engineering Research Semester (SERS) program operated by the Department of Energy. Publisher Copyright: {\textcopyright} 1998 Optical Society of America.; Biomedical Optical Spectroscopy and Diagnostics, BOSD 1998 ; Conference date: 08-03-1998",

year = "1998",

language = "English (US)",

series = "Optics InfoBase Conference Papers",

publisher = "Optica Publishing Group (formerly OSA)",

pages = "20--25",

booktitle = "Biomedical Optical Spectroscopy and Diagnostics, BOSD 1998",

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T1 - Backscattering Mueller Matrix Analysis for Biomedical Optical Diagnostics

AU - Hielscher, Andreas H.

AU - Eick, Angelia A.

AU - Mourant, Judith R.

AU - Chen, D.

AU - Freyer, James P.

AU - Bigio, Irving J.

N1 - Funding Information: This work was supported in part by a grant from the National Institutes of Health (CA71898), a fellowship from the Director's Office at Los Alamos National Laboratory, and funds from the Science and Engineering Research Semester (SERS) program operated by the Department of Energy. Publisher Copyright: © 1998 Optical Society of America.

PY - 1998

Y1 - 1998

N2 - We report on the development of a method that records spatially dependent intensity patterns of polarized light that is diffusely backscattered from highly scattering media. It is demonstrated that these intensity patterns can be used to differentiate turbid media, such as polystyrene-sphere and biological-cell suspensions. Our technique employs polarized light from a He-Ne laser, which is focused onto the surface of the scattering medium. A surface area of approximately 4×4 cm centered on the light input point is imaged through polarization-analysis optics onto a CCD camera. One can observe a large variety of intensity patterns by varying the polarization state of the incident laser light and changing the analyzer configuration to detect different polarization components of the backscattered light. Introducing the Mueller-matrix concept for diffusely backscattered light, a framework is provided to select a subset of measurements that comprehensively describe the optical properties of backscattering media.

AB - We report on the development of a method that records spatially dependent intensity patterns of polarized light that is diffusely backscattered from highly scattering media. It is demonstrated that these intensity patterns can be used to differentiate turbid media, such as polystyrene-sphere and biological-cell suspensions. Our technique employs polarized light from a He-Ne laser, which is focused onto the surface of the scattering medium. A surface area of approximately 4×4 cm centered on the light input point is imaged through polarization-analysis optics onto a CCD camera. One can observe a large variety of intensity patterns by varying the polarization state of the incident laser light and changing the analyzer configuration to detect different polarization components of the backscattered light. Introducing the Mueller-matrix concept for diffusely backscattered light, a framework is provided to select a subset of measurements that comprehensively describe the optical properties of backscattering media.

KW - Backscattering

KW - Cell analysis

KW - Multiple scattering;

KW - Polarization

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M3 - Conference contribution

AN - SCOPUS:85136331718

T3 - Optics InfoBase Conference Papers

SP - 20

EP - 25

BT - Biomedical Optical Spectroscopy and Diagnostics, BOSD 1998

PB - Optica Publishing Group (formerly OSA)

T2 - Biomedical Optical Spectroscopy and Diagnostics, BOSD 1998

Y2 - 8 March 1998

ER -

Backscattering Mueller Matrix Analysis for Biomedical Optical Diagnostics

Abstract

Publication series

Conference

Keywords

ASJC Scopus subject areas

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