TY - JOUR
T1 - Baseline Hypothalamic–Pituitary–Adrenal Axis and Parasympathetic Nervous System Activity Interact to Predict Executive Functions in Low-Income Children
AU - Braren, Stephen H.
AU - Brandes-Aitken, Annie
AU - Perry, Rosemarie E.
AU - Williams, Kevon
AU - Lyons, Krystalle
AU - Rowe-Harriott, Sashana
AU - Blair, Clancy
N1 - Funding Information:
This work was supported by the National Institutes of Child Health and Human Development Grant numbers R01 HD51502 and P01 HD 39667 with co‐funding from the National Institute on Drug Abuse. The role of the first author was also supported by the National Science Foundation Graduate Research Fellowship Program under Grant No. DGE1342536. REP was supported by the National Science Foundation under Grant No. 1810208. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation. None of the authors have any conflicts of interest with regards to the work presented in this manuscript.
Publisher Copyright:
© 2020 International Mind, Brain, and Education Society and Wiley Periodicals LLC
PY - 2021/2
Y1 - 2021/2
N2 - We examined interactions between baseline hypothalamic–pituitary–adrenal (HPA) axis and parasympathetic nervous system (PNS) activity in relation to executive functions (EF) in a sample (n = 1,005) of children in low wealth, nonurban communities at age 48 months. Salivary cortisol and respiratory sinus arrhythmia (RSA) represented baseline HPA axis and PNS activity, respectively. The interaction between RSA and cortisol predicted EF such that children with either lower RSA and lower cortisol, or higher RSA and higher cortisol had higher EF scores. These findings suggest a potential compensatory relation in which the PNS and HPA axis counterbalance each other to support cognition.
AB - We examined interactions between baseline hypothalamic–pituitary–adrenal (HPA) axis and parasympathetic nervous system (PNS) activity in relation to executive functions (EF) in a sample (n = 1,005) of children in low wealth, nonurban communities at age 48 months. Salivary cortisol and respiratory sinus arrhythmia (RSA) represented baseline HPA axis and PNS activity, respectively. The interaction between RSA and cortisol predicted EF such that children with either lower RSA and lower cortisol, or higher RSA and higher cortisol had higher EF scores. These findings suggest a potential compensatory relation in which the PNS and HPA axis counterbalance each other to support cognition.
UR - http://www.scopus.com/inward/record.url?scp=85096698726&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85096698726&partnerID=8YFLogxK
U2 - 10.1111/mbe.12267
DO - 10.1111/mbe.12267
M3 - Article
AN - SCOPUS:85096698726
VL - 15
SP - 61
EP - 66
JO - Mind, Brain, and Education
JF - Mind, Brain, and Education
SN - 1751-2271
IS - 1
ER -