Baseline oxygen saturation comparison between pathologic complete responders and extensive residual cancer cases in response to neoadjuvant chemotherapy

Mirella L. Altoe, Jacqueline E. Gunther, Emerson Lim, Hyun Keol Kim, Jessica Campbell, Hanina Hibshoosh, Katherine Crew, Kevin Kalinsky, Dawn L. Hershman, Andreas H. Hielscher

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    In this retrospective cohort study, we examine the hypothesis that baseline oxygen saturation (SO2%) in contralateral normal tissue can be a quantitative measurement for predicting tumor response to neoadjuvant chemotherapy (NAC). Using our dynamic custom-built dual breast dynamic diffuse optical tomography (DOT) imager, we reconstructed SO2% measurement concentration for 12 stage II or III breast cancer patients. Six patients achieved PCR (RCB-0) and the other half had extensive residual disease (RCB-III). Baseline SO2% in contralateral normal tissue was statistically significantly higher in RCB-III subjects than in PCR (p = 0.025). From ROC analyses, baseline SO2% in contralateral normal breast tissue was able to discriminate PCR from RCB-III patients (AUC 0.889) with sensitivity and specificity of 83%.

    Original languageEnglish (US)
    Title of host publicationOptical Tomography and Spectroscopy of Tissue XII
    EditorsRobert R. Alfano, Eva Marie Sevick-Muraca, Bruce J. Tromberg, Arjun G. Yodh
    PublisherSPIE
    ISBN (Electronic)9781510605596
    DOIs
    StatePublished - 2017
    EventOptical Tomography and Spectroscopy of Tissue XII - San Francisco, United States
    Duration: Jan 30 2017Feb 1 2017

    Publication series

    NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
    Volume10059
    ISSN (Print)1605-7422

    Conference

    ConferenceOptical Tomography and Spectroscopy of Tissue XII
    CountryUnited States
    CitySan Francisco
    Period1/30/172/1/17

    Keywords

    • Breast Imaging
    • Contralat-Eral Normal Breast
    • Diffuse Optical Tomography
    • Neoadjuvant Chemotherapy
    • Oxygen Saturation
    • Tumor Response

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Biomaterials
    • Atomic and Molecular Physics, and Optics
    • Radiology Nuclear Medicine and imaging

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