@inproceedings{59e584b49efa4264abc81b50314fb19d,
title = "Baseline oxygen saturation comparison between pathologic complete responders and extensive residual cancer cases in response to neoadjuvant chemotherapy",
abstract = "In this retrospective cohort study, we examine the hypothesis that baseline oxygen saturation (SO2%) in contralateral normal tissue can be a quantitative measurement for predicting tumor response to neoadjuvant chemotherapy (NAC). Using our dynamic custom-built dual breast dynamic diffuse optical tomography (DOT) imager, we reconstructed SO2% measurement concentration for 12 stage II or III breast cancer patients. Six patients achieved PCR (RCB-0) and the other half had extensive residual disease (RCB-III). Baseline SO2% in contralateral normal tissue was statistically significantly higher in RCB-III subjects than in PCR (p = 0.025). From ROC analyses, baseline SO2% in contralateral normal breast tissue was able to discriminate PCR from RCB-III patients (AUC 0.889) with sensitivity and specificity of 83%.",
keywords = "Breast Imaging, Contralat-Eral Normal Breast, Diffuse Optical Tomography, Neoadjuvant Chemotherapy, Oxygen Saturation, Tumor Response",
author = "Altoe, {Mirella L.} and Gunther, {Jacqueline E.} and Emerson Lim and Kim, {Hyun Keol} and Jessica Campbell and Hanina Hibshoosh and Katherine Crew and Kevin Kalinsky and Hershman, {Dawn L.} and Hielscher, {Andreas H.}",
note = "Publisher Copyright: {\textcopyright} 2017 SPIE.; Optical Tomography and Spectroscopy of Tissue XII ; Conference date: 30-01-2017 Through 01-02-2017",
year = "2017",
doi = "10.1117/12.2251452",
language = "English (US)",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Alfano, {Robert R.} and Sevick-Muraca, {Eva Marie} and Tromberg, {Bruce J.} and Yodh, {Arjun G.}",
booktitle = "Optical Tomography and Spectroscopy of Tissue XII",
}