Permanent ground deformation (PGD) is arguably the most severe hazard for continuous buried pipelines. This paper presents results from two pairs of centrifuge tests designed to investigate the influence of pipe-fault orientation on the behaviours of buried HDPE pipelines subject to strike-slip faulting. The tests results show that, as expected, pipe axial strain is strongly influenced by the pipe-fault orientation angle, whereas the influence of pipe-fault orientation angle on pipe bending strain is minor. The soil-pipe interacting force versus deformation relationship (i.e. p-y relationship) was obtained based on the experimental data. The p-y relationships for the two strike-slip cases with different pipe-fault angles were also compared with the relationships suggested by the ASCE Guidelines (1984). It was found that the experimental p-y relationship is generally compatible to the ASCE Guidelines suggested values.