Behavioral alterations in mice lacking the translation repressor 4E-BP2

Jessica L. Banko, Maayan Merhav, Elad Stern, Nahum Sonenberg, Kobi Rosenblum, Eric Klann

Research output: Contribution to journalArticlepeer-review

Abstract

The requirement for de novo protein synthesis during multiple forms of learning, memory and behavior is well-established; however, we are only beginning to uncover the regulatory mechanisms that govern this process. In order to determine how translation initiation is regulated during neuroplasticity we engineered mutant C57Bl/6J mice that lack the translation repressor eukaryotic initiation factor 4E-binding protein 2 (4E-BP2) and have previously demonstrated that 4E-BP2 plays a critical role in hippocampus-dependent synaptic plasticity and memory. Herein, we examined the 4E-BP2 knockout mice in a battery of paradigms to address motor activity and motor skill learning, anxiety and social dominance behaviors, working memory and conditioned taste aversion. We found that the 4E-BP2 knockout mice demonstrated altered activity in the rotating rod test, light/dark exploration test, spontaneous alternation T-maze and conditioned taste aversion test. The information gained from these studies builds a solid foundation for future studies on the specific role of 4E-BP2 in various types of behavior, and for a broader, more detailed examination of the mechanisms of translational control in the brain.

Original languageEnglish (US)
Pages (from-to)248-256
Number of pages9
JournalNeurobiology of Learning and Memory
Volume87
Issue number2
DOIs
StatePublished - Feb 2007

Keywords

  • Amygdala
  • Behavior
  • Cerebellum
  • Hippocampus
  • Insular cortex
  • Learning and memory
  • Protein synthesis
  • Rota-rod
  • Taste aversion
  • Translation initiation
  • Working memory
  • eIF4E

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

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