Benzoylurea oligomers: Synthetic foldamers that mimic extended α helices

Johanna M. Rodriguez, Andrew D. Hamilton

Research output: Contribution to journalArticlepeer-review

Abstract

Not-so-short and curlies: A new benzoylurea-based foldamer scaffold favors a linear conformation governed by intramolecular hydrogen bonding (see picture, left). The functional groups R are in a staggered arrangement analogous to an α helix. Iterative synthesis and diversification of the functional groups leads to structures with lengths similar to those of naturally occurring α helices (right). (Chemical Equation Presented)

Original languageEnglish (US)
Pages (from-to)8614-8617
Number of pages4
JournalAngewandte Chemie - International Edition
Volume46
Issue number45
DOIs
StatePublished - 2007

Keywords

  • Benzoylurea
  • Foldamers
  • Helical structures
  • Oligomerization
  • Proteomimetics

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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