Bilirubin in a new light

Johannes Broichhagen; Dirk Trauner

doi:10.1002/anie.201307345

Bilirubin in a new light

Johannes Broichhagen, Dirk Trauner

Chemistry

Research output: Contribution to journal › Review article › peer-review

Abstract

Green light for a new method: The protein UnaG shows bright green fluorescence in conjugation with bilirubin. The high affinity and specificity of UnaG allows for the fast and reliable measurement of bilirubin levels in human serum, which could improve the diagnosis of neonatal jaundice and other disorders based on insoluble bilirubin. UnaG expands the toolbox of fluorescent proteins with new features, such as oxygen independence and fast inducibility.

Original language	English (US)
Pages (from-to)	13868-13870
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	52
DOIs	https://doi.org/10.1002/anie.201307345
State	Published - Dec 23 2013

Keywords

bilirubin
fluorescence
genetic engineering
jaundice
proteins

ASJC Scopus subject areas

Catalysis
General Chemistry

Access to Document

10.1002/anie.201307345

Cite this

@article{4c49bb7f6eed49ee912744f4c20db51a,

title = "Bilirubin in a new light",

abstract = "Green light for a new method: The protein UnaG shows bright green fluorescence in conjugation with bilirubin. The high affinity and specificity of UnaG allows for the fast and reliable measurement of bilirubin levels in human serum, which could improve the diagnosis of neonatal jaundice and other disorders based on insoluble bilirubin. UnaG expands the toolbox of fluorescent proteins with new features, such as oxygen independence and fast inducibility.",

keywords = "bilirubin, fluorescence, genetic engineering, jaundice, proteins",

author = "Johannes Broichhagen and Dirk Trauner",

year = "2013",

month = dec,

day = "23",

doi = "10.1002/anie.201307345",

language = "English (US)",

volume = "52",

pages = "13868--13870",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "52",

}

TY - JOUR

T1 - Bilirubin in a new light

AU - Broichhagen, Johannes

AU - Trauner, Dirk

PY - 2013/12/23

Y1 - 2013/12/23

N2 - Green light for a new method: The protein UnaG shows bright green fluorescence in conjugation with bilirubin. The high affinity and specificity of UnaG allows for the fast and reliable measurement of bilirubin levels in human serum, which could improve the diagnosis of neonatal jaundice and other disorders based on insoluble bilirubin. UnaG expands the toolbox of fluorescent proteins with new features, such as oxygen independence and fast inducibility.

AB - Green light for a new method: The protein UnaG shows bright green fluorescence in conjugation with bilirubin. The high affinity and specificity of UnaG allows for the fast and reliable measurement of bilirubin levels in human serum, which could improve the diagnosis of neonatal jaundice and other disorders based on insoluble bilirubin. UnaG expands the toolbox of fluorescent proteins with new features, such as oxygen independence and fast inducibility.

KW - bilirubin

KW - fluorescence

KW - genetic engineering

KW - jaundice

KW - proteins

UR - http://www.scopus.com/inward/record.url?scp=84890784749&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84890784749&partnerID=8YFLogxK

U2 - 10.1002/anie.201307345

DO - 10.1002/anie.201307345

M3 - Review article

C2 - 24353225

AN - SCOPUS:84890784749

SN - 1433-7851

VL - 52

SP - 13868

EP - 13870

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 52

ER -

Bilirubin in a new light

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this