Bio-composite scaffolds containing chitosan/nano-hydroxyapatite/nano-copper-zinc for bone tissue engineering

Anjali Tripathi, Sekaran Saravanan, Soumitri Pattnaik, Ambigapathi Moorthi, Nicola C. Partridge, Nagarajan Selvamurugan

Research output: Contribution to journalArticlepeer-review


The current study involves fabrication and characterization of bio-composite scaffolds containing chitosan (CS), nano-hydroxyapatite (nHAp) and Cu-Zn alloy nanoparticles (nCu-Zn) by freeze drying technique. The fabricated composite scaffolds (CS/nHAp and CS/nHAp/nCu-Zn) were characterized by SEM, EDX, XRD and FT-IR studies. The addition of nCu-Zn in the CS/nHAp scaffolds significantly increased swelling, decreased degradation, increased protein adsorption, and increased antibacterial activity. The CS/nHAp/nCu-Zn scaffolds had no toxicity towards rat osteoprogenitor cells. So the developed CS/nHAp/nCu-Zn scaffolds have advantageous and potential applications over the CS-nHAp scaffolds for bone tissue engineering.

Original languageEnglish (US)
Pages (from-to)294-299
Number of pages6
JournalInternational Journal of Biological Macromolecules
Issue number1
StatePublished - Jan 1 2012


  • Antibacterial activity
  • Bone
  • Chitosan
  • Copper-zinc alloy
  • Cytotoxicity
  • Nano-hydroxyapatite

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Economics and Econometrics
  • General Energy


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