TY - JOUR
T1 - Bio-composite scaffolds containing chitosan/nano-hydroxyapatite/nano-copper-zinc for bone tissue engineering
AU - Tripathi, Anjali
AU - Saravanan, Sekaran
AU - Pattnaik, Soumitri
AU - Moorthi, Ambigapathi
AU - Partridge, Nicola C.
AU - Selvamurugan, Nagarajan
N1 - Funding Information:
We thank the SRM University for providing the fund under the M. Tech. Students Research Program. We also thank the Indian Council for Medical Research, India for financial support (Grant Nos. 5/13/2009-NCD-III ; 80/10/2010-BMS to N.S.).
PY - 2012/1/1
Y1 - 2012/1/1
N2 - The current study involves fabrication and characterization of bio-composite scaffolds containing chitosan (CS), nano-hydroxyapatite (nHAp) and Cu-Zn alloy nanoparticles (nCu-Zn) by freeze drying technique. The fabricated composite scaffolds (CS/nHAp and CS/nHAp/nCu-Zn) were characterized by SEM, EDX, XRD and FT-IR studies. The addition of nCu-Zn in the CS/nHAp scaffolds significantly increased swelling, decreased degradation, increased protein adsorption, and increased antibacterial activity. The CS/nHAp/nCu-Zn scaffolds had no toxicity towards rat osteoprogenitor cells. So the developed CS/nHAp/nCu-Zn scaffolds have advantageous and potential applications over the CS-nHAp scaffolds for bone tissue engineering.
AB - The current study involves fabrication and characterization of bio-composite scaffolds containing chitosan (CS), nano-hydroxyapatite (nHAp) and Cu-Zn alloy nanoparticles (nCu-Zn) by freeze drying technique. The fabricated composite scaffolds (CS/nHAp and CS/nHAp/nCu-Zn) were characterized by SEM, EDX, XRD and FT-IR studies. The addition of nCu-Zn in the CS/nHAp scaffolds significantly increased swelling, decreased degradation, increased protein adsorption, and increased antibacterial activity. The CS/nHAp/nCu-Zn scaffolds had no toxicity towards rat osteoprogenitor cells. So the developed CS/nHAp/nCu-Zn scaffolds have advantageous and potential applications over the CS-nHAp scaffolds for bone tissue engineering.
KW - Antibacterial activity
KW - Bone
KW - Chitosan
KW - Copper-zinc alloy
KW - Cytotoxicity
KW - Nano-hydroxyapatite
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U2 - 10.1016/j.ijbiomac.2011.11.013
DO - 10.1016/j.ijbiomac.2011.11.013
M3 - Article
C2 - 22123094
AN - SCOPUS:83555165148
SN - 0141-8130
VL - 50
SP - 294
EP - 299
JO - International Journal of Biological Macromolecules
JF - International Journal of Biological Macromolecules
IS - 1
ER -