"Bio"-macromolecules: polymer-protein conjugates as emerging scaffolds for therapeutics

Dorothee E. Borchmann, Tom P. Carberry, Marcus Weck

Research output: Contribution to journalArticlepeer-review

Abstract

Polymer-protein conjugates are biohybrid macromolecules derived from covalently connecting synthetic polymers with polypeptides. The resulting materials combine the properties of both worlds: chemists can engineer polymers to stabilize proteins, to add functionality, or to enhance activity; whereas biochemists can exploit the specificity and complexity that Nature has bestowed upon its macromolecules. This has led to a wealth of applications, particularly within the realm of biomedicine. Polymer-protein conjugation has expanded to include scaffolds for drug delivery, tissue engineering, and microbial inhibitors. This feature article reflects upon recent developments in the field and discusses the applications of these hybrids from a biomaterials standpoint.

Original languageEnglish (US)
Pages (from-to)27-43
Number of pages17
JournalMacromolecular Rapid Communications
Volume35
Issue number1
DOIs
StatePublished - Jan 2014

Keywords

  • bioengineering
  • biological applications of polymers
  • biomaterials
  • poly(ethylene glycol)
  • proteins

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

Fingerprint Dive into the research topics of '"Bio"-macromolecules: polymer-protein conjugates as emerging scaffolds for therapeutics'. Together they form a unique fingerprint.

Cite this