Bioactive Compounds From Microalgae: Current Development and Prospects

W. Fu, D. R. Nelson, Z. Yi, M. Xu, B. Khraiwesh, K. Jijakli, A. Chaiboonchoe, A. Alzahmi, D. Al-Khairy, S. Brynjolfsson, K. Salehi-Ashtiani

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Microalgae make up the largest and likely most diverse group of photosynthetic organisms in freshwater and marine systems. As new technologies are emerging for the study of bioactive compounds from microalgae, this group is drawing attention as a promising source of natural products that have wide applications in the food and pharmaceutical industries. Algae-derived bioactive compounds are attractive resources for drug screening, given their tremendous structural diversity and biological availability. In this chapter, we first discuss medicinally important products, such as carotenoids, including β-carotene, fucoxanthin, astaxanthin, and lutein, as well as essential fatty acids that originate in microalgae. We then briefly introduce screening assays for antioxidant, antimicrobial, antiviral, anticancer, and immunomodulatory effects, and explore biosynthesis of natural products, which have been widely used in food and cosmetics for their antioxidant effects and nutritional value, and we discuss the potential use of fucoxanthin and its derivatives as anticancer agents. In addition, we describe health benefits of the essential fatty acids eicosapentaenoic acid and docosahexaenoic acid. Further, this chapter emphasizes that microalgae provide a rich source of compounds for therapeutic drug screening and describes examples of screening assays for detection of biological activities of algae-derived compounds.

Original languageEnglish (US)
Title of host publicationStudies in Natural Products Chemistry
PublisherElsevier B.V.
Pages199-225
Number of pages27
DOIs
StatePublished - Jan 1 2017

Publication series

NameStudies in Natural Products Chemistry
Volume54
ISSN (Print)1572-5995

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Keywords

  • Bioactivities
  • Biological assays
  • Carotenoids
  • Essential fatty acids
  • Green algae and diatoms

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry

Cite this

Fu, W., Nelson, D. R., Yi, Z., Xu, M., Khraiwesh, B., Jijakli, K., Chaiboonchoe, A., Alzahmi, A., Al-Khairy, D., Brynjolfsson, S., & Salehi-Ashtiani, K. (2017). Bioactive Compounds From Microalgae: Current Development and Prospects. In Studies in Natural Products Chemistry (pp. 199-225). (Studies in Natural Products Chemistry; Vol. 54). Elsevier B.V.. https://doi.org/10.1016/B978-0-444-63929-5.00006-1