TY - JOUR
T1 - Bioactivity of strontium-monetite coatings for biomedical applications
AU - Navarro da Rocha, Daniel
AU - Cruz, Leila Rosa de Oliveira
AU - de Campos, José Brant
AU - Santos, Jheison Lopes dos
AU - Marçal, Rubens L.Santana Blazutti
AU - Mijares, Dindo Q.
AU - Barbosa, Rafael Maza
AU - Coelho, Paulo G.
AU - Prado da Silva, Marcelo H.
N1 - Funding Information:
The authors would like to acknowledge Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro ( FAPERJ ) ( 2015005263 , Conselho Nacional de Desenvolvimento Científico e Tecnológico ( CNPq ) ( 140144/2012-9 ) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior ( CAPES ) ( 10.980/13-0 ) for the grants, and the institutions IME, NYUCD and CBPF for their cooperation and support for the paper. We are grateful to Dr. Isac de Castro (Division of Molecular Medicine, Department of Medicine, Clinical Hospital, University of São Paulo, Brazil) for excellent statistical assistance. The authors declare no conflicts of interest related to this study.
Funding Information:
The authors would like to acknowledge Funda??o Carlos Chagas Filho de Amparo ? Pesquisa do Estado do Rio de Janeiro (FAPERJ) (2015005263, Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico (CNPq) (140144/2012-9) and Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES) (10.980/13-0) for the grants, and the institutions IME, NYUCD and CBPF for their cooperation and support for the paper. We are grateful to Dr. Isac de Castro (Division of Molecular Medicine, Department of Medicine, Clinical Hospital, University of S?o Paulo, Brazil) for excellent statistical assistance. The authors declare no conflicts of interest related to this study.
Publisher Copyright:
© 2019 Elsevier Ltd and Techna Group S.r.l.
PY - 2019/4/15
Y1 - 2019/4/15
N2 - The bioactivity of calcium phosphate (CaP) coatings can be controlled by different CaP phase precipitation and/or addition of foreign ions to their crystal lattice. Cationic substitution of strontium (Sr) into CaP coatings has gained a great attention due to the unique potential of Sr ions on stimulating new bone formation while inhibiting bone resorption. In this study, a novel route was used for producing Sr-substituted calcium phosphate coating on metallic substrates, containing 5 mol%, 10 mol% and 15 mol% Sr concentration, by chemical deposition method. The obtained Sr-substituted calcium phosphate coatings were structurally characterized by X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR) analyses. The presence of strontium ions into calcium phosphate phase fostered monetite precipitation, instead of brushite, and this cationic substitution was investigated by Rietveld refinement method. FEG-SEM analysis showed the bioactivity behavior by the precipitation of characteristic bone-like apatite on the 5% Sr-monetite and HA coatings after 14 days of incubation, using McCoy culture medium. The biological performance of the coated surfaces showed that hDPSCs viability was enhanced in the presence of Sr 2+ ion concentration up to 10 mol% (p < 0.05) when compared to the uncoated titanium substrates and hydroxyapatite coatings. The results suggested the 5% Sr-monetite as a potential alternative for hydroxyapatite coatings, because of the improved biological responses in this study.
AB - The bioactivity of calcium phosphate (CaP) coatings can be controlled by different CaP phase precipitation and/or addition of foreign ions to their crystal lattice. Cationic substitution of strontium (Sr) into CaP coatings has gained a great attention due to the unique potential of Sr ions on stimulating new bone formation while inhibiting bone resorption. In this study, a novel route was used for producing Sr-substituted calcium phosphate coating on metallic substrates, containing 5 mol%, 10 mol% and 15 mol% Sr concentration, by chemical deposition method. The obtained Sr-substituted calcium phosphate coatings were structurally characterized by X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR) analyses. The presence of strontium ions into calcium phosphate phase fostered monetite precipitation, instead of brushite, and this cationic substitution was investigated by Rietveld refinement method. FEG-SEM analysis showed the bioactivity behavior by the precipitation of characteristic bone-like apatite on the 5% Sr-monetite and HA coatings after 14 days of incubation, using McCoy culture medium. The biological performance of the coated surfaces showed that hDPSCs viability was enhanced in the presence of Sr 2+ ion concentration up to 10 mol% (p < 0.05) when compared to the uncoated titanium substrates and hydroxyapatite coatings. The results suggested the 5% Sr-monetite as a potential alternative for hydroxyapatite coatings, because of the improved biological responses in this study.
KW - B. Surfaces
KW - C. Chemical properties
KW - D. Apatite
KW - E. Biomedical applications
UR - http://www.scopus.com/inward/record.url?scp=85059699310&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85059699310&partnerID=8YFLogxK
U2 - 10.1016/j.ceramint.2019.01.051
DO - 10.1016/j.ceramint.2019.01.051
M3 - Article
AN - SCOPUS:85059699310
SN - 0272-8842
VL - 45
SP - 7568
EP - 7579
JO - Ceramics International
JF - Ceramics International
IS - 6
ER -