Biochemical mechanisms for translational regulation in synaptic plasticity

Eric Klann, Thomas E. Dever

Research output: Contribution to journalReview articlepeer-review


Changes in gene expression are required for long-lasting synaptic plasticity and long-term memory in both invertebrates and vertebrates. Regulation of local protein synthesis allows synapses to control synaptic strength independently of messenger RNA synthesis in the cell body. Recent reports indicate that several biochemical signalling cascades couple neurotransmitter and neurotrophin receptors to translational regulatory factors in protein synthesis-dependent forms of synaptic plasticity and memory. In this review, we highlight these translational regulatory mechanisms and the signalling pathways that govern the expression of synaptic plasticity in response to specific types of neuronal stimulation.

Original languageEnglish (US)
Pages (from-to)931-942
Number of pages12
JournalNature Reviews Neuroscience
Issue number12
StatePublished - Dec 2004

ASJC Scopus subject areas

  • General Neuroscience


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