Bioengineering strategies for inducing tolerance in autoimmune diabetes

Steinunn Baekkeskov; Jeffrey A. Hubbell; Edward A. Phelps

doi:10.1016/j.addr.2017.06.007

Bioengineering strategies for inducing tolerance in autoimmune diabetes

Steinunn Baekkeskov, Jeffrey A. Hubbell, Edward A. Phelps

Chemical and Biomolecular Engineering

Research output: Contribution to journal › Review article › peer-review

Abstract

Type 1 diabetes is an autoimmune disease marked by the destruction of insulin-producing beta cells in the pancreatic islets. Strategies to delay onset or prevent the autoimmune recognition of beta cell antigens or T cell-mediated killing of beta cells have mainly focused on systemic immunomodulation and antigen-specific immunotherapy. To bridge the fields of type 1 diabetes immunology and biomaterials engineering, this article will review recent trends in the etiology of type 1 diabetes immunopathology and will focus on the contributions of emerging bioengineered strategies in the fight against beta cell autoimmunity in type 1 diabetes.

Original language	English (US)
Pages (from-to)	256-265
Number of pages	10
Journal	Advanced Drug Delivery Reviews
Volume	114
DOIs	https://doi.org/10.1016/j.addr.2017.06.007
State	Published - May 15 2017

Keywords

Autoimmunity
Biomaterials
Tolerance
Type 1 diabetes

ASJC Scopus subject areas

Pharmaceutical Science

Access to Document

10.1016/j.addr.2017.06.007

Cite this

@article{c64bae60cbc74a998776a90ba2f68cfb,

title = "Bioengineering strategies for inducing tolerance in autoimmune diabetes",

abstract = "Type 1 diabetes is an autoimmune disease marked by the destruction of insulin-producing beta cells in the pancreatic islets. Strategies to delay onset or prevent the autoimmune recognition of beta cell antigens or T cell-mediated killing of beta cells have mainly focused on systemic immunomodulation and antigen-specific immunotherapy. To bridge the fields of type 1 diabetes immunology and biomaterials engineering, this article will review recent trends in the etiology of type 1 diabetes immunopathology and will focus on the contributions of emerging bioengineered strategies in the fight against beta cell autoimmunity in type 1 diabetes.",

keywords = "Autoimmunity, Biomaterials, Tolerance, Type 1 diabetes",

author = "Steinunn Baekkeskov and Hubbell, {Jeffrey A.} and Phelps, {Edward A.}",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier B.V.",

year = "2017",

month = may,

day = "15",

doi = "10.1016/j.addr.2017.06.007",

language = "English (US)",

volume = "114",

pages = "256--265",

journal = "Advanced Drug Delivery Reviews",

issn = "0169-409X",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Bioengineering strategies for inducing tolerance in autoimmune diabetes

AU - Baekkeskov, Steinunn

AU - Hubbell, Jeffrey A.

AU - Phelps, Edward A.

PY - 2017/5/15

Y1 - 2017/5/15

N2 - Type 1 diabetes is an autoimmune disease marked by the destruction of insulin-producing beta cells in the pancreatic islets. Strategies to delay onset or prevent the autoimmune recognition of beta cell antigens or T cell-mediated killing of beta cells have mainly focused on systemic immunomodulation and antigen-specific immunotherapy. To bridge the fields of type 1 diabetes immunology and biomaterials engineering, this article will review recent trends in the etiology of type 1 diabetes immunopathology and will focus on the contributions of emerging bioengineered strategies in the fight against beta cell autoimmunity in type 1 diabetes.

AB - Type 1 diabetes is an autoimmune disease marked by the destruction of insulin-producing beta cells in the pancreatic islets. Strategies to delay onset or prevent the autoimmune recognition of beta cell antigens or T cell-mediated killing of beta cells have mainly focused on systemic immunomodulation and antigen-specific immunotherapy. To bridge the fields of type 1 diabetes immunology and biomaterials engineering, this article will review recent trends in the etiology of type 1 diabetes immunopathology and will focus on the contributions of emerging bioengineered strategies in the fight against beta cell autoimmunity in type 1 diabetes.

KW - Autoimmunity

KW - Biomaterials

KW - Tolerance

KW - Type 1 diabetes

UR - http://www.scopus.com/inward/record.url?scp=85021163926&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85021163926&partnerID=8YFLogxK

U2 - 10.1016/j.addr.2017.06.007

DO - 10.1016/j.addr.2017.06.007

M3 - Review article

C2 - 28625830

AN - SCOPUS:85021163926

SN - 0169-409X

VL - 114

SP - 256

EP - 265

JO - Advanced Drug Delivery Reviews

JF - Advanced Drug Delivery Reviews

ER -

Bioengineering strategies for inducing tolerance in autoimmune diabetes

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this