@article{6146ec6a6c8a4193bc8634cb9525aa26,
title = "Biomimetic Synthesis of (+)-Aspergillin PZ",
abstract = "The cytochalasans are a large family of polyketide natural products with potent bioactivities. Amongst them, the aspochalasins show particularly intricate and fascinating structures. To gain insight into their structural diversity and innate reactivity, we have developed a rapid synthesis of aspochalasin D, the central member of the family. It proceeded in 13 steps starting from divinyl carbinol and utilized a high pressure Diels–Alder reaction that features high regio- and stereoselectivity. So far, our work has culminated in a biomimetic synthesis of aspergillin PZ, an intricate pentacyclic aspochalasan.",
keywords = "Diels–Alder cycloaddition, biomimetic synthesis, cytochalasans, high-pressure chemistry, total synthesis",
author = "Reyes, {Julius R.} and Nils Winter and Lukas Spessert and Dirk Trauner",
note = "Funding Information: We thank the Deutsche Forschungsgemeinschaft (SFB 749), the Alexander von Humboldt Stiftung, and the National Institutes of Health (1R01GM126228) for financial support of this work. J.R.R. is grateful to the Alexander von Humboldt Stiftung and the Carl Friedrich von Siemens Stiftung for a postdoctoral fellowship. We thank Dr. Peter Mayer (LMU Munich) for X-ray structure analysis and Martin Maier (NYU) and Dr. Giulio Volpin (NYU) for computational analysis of aspergillin PZ. Furthermore, Dr. Antonio Rizzo (Seoul National University), Dr. Felix Hartrampf (Boston College) and Prof. Dr. Hong-Dong Hao (Northwest A&F University) are warmly acknowledged for insightful discussions. Publisher Copyright: {\textcopyright} 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",
year = "2018",
month = nov,
day = "19",
doi = "10.1002/anie.201809703",
language = "English (US)",
volume = "57",
pages = "15587--15591",
journal = "Angewandte Chemie - International Edition",
issn = "1433-7851",
publisher = "John Wiley and Sons Ltd",
number = "47",
}