Biomimetic synthesis of (±)-merochlorin B

Robin Meier, Sebastian Strych, Dirk Trauner

Research output: Contribution to journalArticlepeer-review

Abstract

A short total synthesis, guided by biosynthetic considerations, of racemic merochlorin B is presented. The formation of its isomer, merochlorin A, was not observed under the conditions. Key steps include a directed ortho-metalation (DoM), a selective demethylation, an ortho-allylation, and an oxidative [3 + 2]-cycloaddition mediated by an iodine(III) reagent.

Original languageEnglish (US)
Pages (from-to)2634-2637
Number of pages4
JournalOrganic Letters
Volume16
Issue number10
DOIs
StatePublished - May 16 2014

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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