Biomimetic synthesis of the IDO inhibitors exiguamine A and B

Matthew Volgraf, Jean Philip Lumb, Harry C. Brastianos, Gavin Carr, Marco K.W. Chung, Martin Münzel, A. Grant Mauk, Raymond J. Andersen, Dirk Trauner

Research output: Contribution to journalArticlepeer-review

Abstract

Biomimetic synthesis is an attempt to assemble natural products along biosynthetic lines without recourse to the full enzymatic machinery of nature. We exemplify this with a total synthesis of exiguamine A and the newly isolated natural product exiguamine B. The most noteworthy feature of this work is an oxidative endgame drawing from the complex chemistry of catecholamines, which allows for ready access to a new class of nanomolar indoleamine-2,3-dioxygenase inhibitors.

Original languageEnglish (US)
Pages (from-to)535-537
Number of pages3
JournalNature Chemical Biology
Volume4
Issue number9
DOIs
StatePublished - Sep 2008

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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