Biomineralization-an active or passive process?

Thorsten Kirsch

    Research output: Contribution to journalReview article

    Abstract

    Biomineralization is a multifactorial and complex process, which results in the deposition of mineral crystals in the extracellular matrix of various tissues. Physiological mineralization is restricted to tissues, such as bones, teeth, and certain areas of cartilage. Pathological or ectopic mineralization can occur in many soft tissues, including articular cartilage, cardiovascular tissues, kidney, ligaments, and tendons, and can lead to serious problems. Therefore, the understanding of factors and mechanisms that regulate the mineralization process is essential for the development of novel therapeutic strategies to prevent or inhibit ectopic mineralization. This review will discuss some of the mechanisms and factors that regulate physiological mineralization and their potential roles in ectopic mineralization. Finally, potential therapeutic approaches for the treatment of ectopic mineralization are being discussed.

    Original languageEnglish (US)
    Pages (from-to)438-445
    Number of pages8
    JournalConnective Tissue Research
    Volume53
    Issue number6
    DOIs
    StatePublished - Dec 2012

    Keywords

    • annexin
    • biomineralization
    • ectopic mineralization
    • matrix vesicles

    ASJC Scopus subject areas

    • Rheumatology
    • Biochemistry
    • Orthopedics and Sports Medicine
    • Molecular Biology
    • Cell Biology

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