Biophysical properties of dynein in vivo

George T. Shubeita, Babu J.N. Reddy, Steven P. Gross

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter discusses what is known about dynein function in vivo, especially with regards to biophysical properties such as force production, velocity and travel distances, and also how such functions are regulated. Dynein frequently works in ensembles, e.g. with multiple motors and co-factors working together to transport a cargo. The chapter discusses how regulation that directly targets single-molecule properties ultimately alters ensemble function.

Original languageEnglish (US)
Title of host publicationDyneins
Subtitle of host publicationDynein Mechanics, Dysfunction, and Disease: Second Edition
PublisherElsevier
Pages136-151
Number of pages16
Volume2
ISBN (Electronic)9780128097014
ISBN (Print)9780128094709
DOIs
StatePublished - Nov 28 2017

Keywords

  • Dynactin
  • Dynein
  • Group function
  • Lis1
  • Multiple motors
  • NudE

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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