Biphasic theory: breakthrough understanding of tooth movement

Mani Alikhani, Chinapa Sangsuwon, Sarah Alansari, Jeanne M. Nervina, Cristina C. Teixeira

Research output: Contribution to journalReview article

Abstract

Background: Research on the biology of orthodontic tooth movement has led to the prevailing compression-tension theory, which divides the response to orthodontic force into two opposing reactions spatially separated: on the compression side, osteoclasts resorb bone to create space for tooth movement, whereas on the tension side, osteoblasts form bone to restore the alveolar bone structure. Methods: Here we take a critical look at the literature on how force-induced inflammation, the periodontal ligament, osteoclasts, and osteoblasts contribute to the biological reaction to orthodontic force. We introduce new evidence that supports a novel theory to explain the biology of tooth movement—the Biphasic Theory. Results: The Biphasic Theory of Orthodontic Tooth Movement divides tooth movement into the initial Catabolic Phase, during which osteoclasts resorb bone at both compression and tension sites, and the Anabolic Phase, which occurs subsequently to restore alveolar bone to its pretreatment levels. Conclusions: The Biphasic Theory of Tooth Movement successfully addresses shortfalls in the Compression-Tension Theory of Tooth Movement, provides clinicians with a better understanding of how orthodontic forces move teeth, and offers new targets for therapies aimed at accelerating tooth movement.

Original languageEnglish (US)
Pages (from-to)82-88
Number of pages7
JournalJournal of the World Federation of Orthodontists
Volume7
Issue number3
DOIs
StatePublished - Sep 2018

Keywords

  • Anabolic
  • Biphasic theory
  • Catabolic
  • Orthodontics
  • Tooth movement

ASJC Scopus subject areas

  • Orthodontics

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