Block liposome and nanotube formation is a general phenomenon of two-component membranes containing multivalent lipids

Alexandra Zidovska, Kai K. Ewert, Joel Quispe, Bridget Carragher, Clinton S. Potter, Cyrus R. Safinya

    Research output: Contribution to journalArticle

    Abstract

    We report a study on the formation of block liposomes (BLs) and nanotubes from membranes comprising mixtures of membrane curvature-stabilizing multivalent cationic lipids MVL3(3+) and MVL5(5+) with neutral 1,2-dioleoyl-sn-glycero-3- phosphatidylcholine (DOPC). In conjunction with prior work on MVLBG2(16+), our experiments suggest that BL and nanotube formation is a general phenomenon in membranes containing multivalent lipids, thus enhancing the relevance of BLs for applications such as gene/drug storage and delivery or templating.

    Original languageEnglish (US)
    Pages (from-to)8363-8369
    Number of pages7
    JournalSoft Matter
    Volume7
    Issue number18
    DOIs
    StatePublished - Sep 21 2011

    ASJC Scopus subject areas

    • Chemistry(all)
    • Condensed Matter Physics

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  • Cite this

    Zidovska, A., Ewert, K. K., Quispe, J., Carragher, B., Potter, C. S., & Safinya, C. R. (2011). Block liposome and nanotube formation is a general phenomenon of two-component membranes containing multivalent lipids. Soft Matter, 7(18), 8363-8369. https://doi.org/10.1039/c1sm05481c