TY - JOUR
T1 - Body size and weight change over adulthood and risk of breast cancer by menopausal and hormone receptor status
T2 - a pooled analysis of 20 prospective cohort studies
AU - van den Brandt, Piet A.
AU - Ziegler, Regina G.
AU - Wang, Molin
AU - Hou, Tao
AU - Li, Ruifeng
AU - Adami, Hans Olov
AU - Agnoli, Claudia
AU - Bernstein, Leslie
AU - Buring, Julie E.
AU - Chen, Yu
AU - Connor, Avonne E.
AU - Eliassen, A. Heather
AU - Genkinger, Jeanine M.
AU - Gierach, Gretchen
AU - Giles, Graham G.
AU - Goodman, Gary G.
AU - Håkansson, Niclas
AU - Krogh, Vittorio
AU - Le Marchand, Loic
AU - Lee, I. Min
AU - Liao, Linda M.
AU - Martinez, M. Elena
AU - Miller, Anthony B.
AU - Milne, Roger L.
AU - Neuhouser, Marian L.
AU - Patel, Alpa V.
AU - Prizment, Anna
AU - Robien, Kim
AU - Rohan, Thomas E.
AU - Sawada, Norie
AU - Schouten, Leo J.
AU - Sinha, Rashmi
AU - Stolzenberg-Solomon, Rachael Z.
AU - Teras, Lauren R.
AU - Tsugane, Shoichiro
AU - Visvanathan, Kala
AU - Weiderpass, Elisabete
AU - White, Kami K.
AU - Willett, Walter C.
AU - Wolk, Alicja
AU - Zeleniuch-Jacquotte, Anne
AU - Smith-Warner, Stephanie A.
N1 - Publisher Copyright:
© 2020, The Author(s).
PY - 2021/1
Y1 - 2021/1
N2 - Associations between anthropometric factors and breast cancer (BC) risk have varied inconsistently by estrogen and/or progesterone receptor (ER/PR) status. Associations between prediagnostic anthropometric factors and risk of premenopausal and postmenopausal BC overall and ER/PR status subtypes were investigated in a pooled analysis of 20 prospective cohorts, including 36,297 BC cases among 1,061,915 women, using multivariable Cox regression analyses, controlling for reproductive factors, diet and other risk factors. We estimated dose–response relationships and tested for nonlinear associations using restricted cubic splines. Height showed positive, linear associations for premenopausal and postmenopausal BC risk (6–7% RR increase per 5 cm increment), with stronger associations for receptor-positive subtypes. Body mass index (BMI) at cohort baseline was strongly inversely associated with premenopausal BC risk, and strongly positively—and nonlinearly—associated with postmenopausal BC (especially among women who never used hormone replacement therapy). This was primarily observed for receptor-positive subtypes. Early adult BMI (at 18–20 years) showed inverse, linear associations for premenopausal and postmenopausal BC risk (21% and 11% RR decrease per 5 kg/m2, respectively) with stronger associations for receptor-negative subtypes. Adult weight gain since 18–20 years was positively associated with postmenopausal BC risk, stronger for receptor-positive subtypes, and among women who were leaner in early adulthood. Women heavier in early adulthood generally had reduced premenopausal BC risk, independent of later weight gain. Positive associations between height, baseline (adult) BMI, adult weight gain and postmenopausal BC risk were substantially stronger for hormone receptor-positive versus negative subtypes. Premenopausal BC risk was positively associated with height, but inversely with baseline BMI and weight gain (mostly in receptor-positive subtypes). Inverse associations with early adult BMI seemed stronger in receptor-negative subtypes of premenopausal and postmenopausal BC.
AB - Associations between anthropometric factors and breast cancer (BC) risk have varied inconsistently by estrogen and/or progesterone receptor (ER/PR) status. Associations between prediagnostic anthropometric factors and risk of premenopausal and postmenopausal BC overall and ER/PR status subtypes were investigated in a pooled analysis of 20 prospective cohorts, including 36,297 BC cases among 1,061,915 women, using multivariable Cox regression analyses, controlling for reproductive factors, diet and other risk factors. We estimated dose–response relationships and tested for nonlinear associations using restricted cubic splines. Height showed positive, linear associations for premenopausal and postmenopausal BC risk (6–7% RR increase per 5 cm increment), with stronger associations for receptor-positive subtypes. Body mass index (BMI) at cohort baseline was strongly inversely associated with premenopausal BC risk, and strongly positively—and nonlinearly—associated with postmenopausal BC (especially among women who never used hormone replacement therapy). This was primarily observed for receptor-positive subtypes. Early adult BMI (at 18–20 years) showed inverse, linear associations for premenopausal and postmenopausal BC risk (21% and 11% RR decrease per 5 kg/m2, respectively) with stronger associations for receptor-negative subtypes. Adult weight gain since 18–20 years was positively associated with postmenopausal BC risk, stronger for receptor-positive subtypes, and among women who were leaner in early adulthood. Women heavier in early adulthood generally had reduced premenopausal BC risk, independent of later weight gain. Positive associations between height, baseline (adult) BMI, adult weight gain and postmenopausal BC risk were substantially stronger for hormone receptor-positive versus negative subtypes. Premenopausal BC risk was positively associated with height, but inversely with baseline BMI and weight gain (mostly in receptor-positive subtypes). Inverse associations with early adult BMI seemed stronger in receptor-negative subtypes of premenopausal and postmenopausal BC.
KW - Body height
KW - Body weight
KW - Breast neoplasms
KW - Cohort studies
KW - Estrogen receptor
KW - Weight change
UR - http://www.scopus.com/inward/record.url?scp=85094649920&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85094649920&partnerID=8YFLogxK
U2 - 10.1007/s10654-020-00688-3
DO - 10.1007/s10654-020-00688-3
M3 - Article
C2 - 33128203
AN - SCOPUS:85094649920
SN - 0393-2990
VL - 36
SP - 37
EP - 55
JO - European Journal of Epidemiology
JF - European Journal of Epidemiology
IS - 1
ER -