Bone Proteinases

Minnkyoung Lee, Emi Shimizu, Stephen M. Krane, Nicola C. Partridge

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter surveys the current knowledge of the proteinases expressed in bone. Although previously the osteoclast was considered to be the main producer of proteinases in bone, it has become increasingly clear that osteoblasts play a significant role in the production of many of these proteinases. Based on the structure and the catalytic mechanism of the active site involving particular amino acid residues and zinc, proteinases can be classified into four groups: metalloproteinases e.g., collagenase-3; serine proteinases, e.g., plasminogen activator; cysteine proteinases, e.g., cathepsin K; and aspartic proteinases, e.g., cathepsin D. The osteoblast has the ability to produce proteinases of all four classes, but far more is known about their production of collagenase and plasminogen activators, at least in vitro. The absolute role of any of these osteoblastic enzymes in vivo is still not fully known. Further work with knockouts of the respective enzymes is likely the only way to determine their required functions. These roles may not be restricted to assisting in the resorption process but may include functions to regulate bone development. Additionally, the osteoclast produces MMP-9 and cathepsin K, which appear to have similar roles in the two diverse processes.

Original languageEnglish (US)
Title of host publicationPrinciples of Bone Biology, Two-Volume Set
PublisherElsevier Inc.
Pages367-384
Number of pages18
Volume1
ISBN (Print)9780123738844
DOIs
StatePublished - 2008

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Lee, M., Shimizu, E., Krane, S. M., & Partridge, N. C. (2008). Bone Proteinases. In Principles of Bone Biology, Two-Volume Set (Vol. 1, pp. 367-384). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-373884-4.00038-0