Abstract
Purpose: To investigate the bone regenerative effect of polymer and collagen incorporation to synthetic bone graft materials. Materials and Methods: The bone ingrowth of biphasic graft materials was tested in a rabbit calvaria defect model after chemical characterization: HA/TCP (25%/75%) with collagen, HA/TCP (25%/75%) without collagen, (HA/TCP)/PLGA (85%/15%) with collagen, (HA/TCP)/PLGA (65%/35%) with collagen and a commercially available (HA/TCP)/PLGA (50%/50%) (ReOss™, Intra-Lock International, Boca Raton, FL) was used as control. After 4 and 8 weeks, the retrieved samples were subjected to histomorphometrical analysis. Results: Histomorphometry presented no significant differences concerning the bone formation between the different groups at both 4 and 8 weeks. Evidently, the (HA/TCP)/PLGA (65%/35%) with collagen presented the least amount of soft tissue incorporation within the defect. The same group possessed higher amounts of bone graft material within the defect throughout the 8-week observation period, whereas the other groups seemed to decrease in volume from 4 to 8 weeks. Conclusion: Changing the PLGA percentage to 35% within the biphasic graft material seemed to maintain its volume and prevented soft tissue migration, which could be clinically beneficial.
Original language | English (US) |
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Pages (from-to) | 149-154 |
Number of pages | 6 |
Journal | Implant dentistry |
Volume | 24 |
Issue number | 2 |
DOIs | |
State | Published - Apr 4 2015 |
Keywords
- bone grafts
- histomorphometry
- hydroxyapatite
- poly-lactic-co-glycolic acid
- tricalcium phosphate
ASJC Scopus subject areas
- Oral Surgery