Bone regenerative potential of modified biphasic graft materials

Rehan Khan, Lukasz Witek, Matthew Breit, Dinely Colon, Nick Tovar, Malvin N. Janal, Ryo Jimbo, Paulo G. Coelho

Research output: Contribution to journalArticlepeer-review


Purpose: To investigate the bone regenerative effect of polymer and collagen incorporation to synthetic bone graft materials. Materials and Methods: The bone ingrowth of biphasic graft materials was tested in a rabbit calvaria defect model after chemical characterization: HA/TCP (25%/75%) with collagen, HA/TCP (25%/75%) without collagen, (HA/TCP)/PLGA (85%/15%) with collagen, (HA/TCP)/PLGA (65%/35%) with collagen and a commercially available (HA/TCP)/PLGA (50%/50%) (ReOss™, Intra-Lock International, Boca Raton, FL) was used as control. After 4 and 8 weeks, the retrieved samples were subjected to histomorphometrical analysis. Results: Histomorphometry presented no significant differences concerning the bone formation between the different groups at both 4 and 8 weeks. Evidently, the (HA/TCP)/PLGA (65%/35%) with collagen presented the least amount of soft tissue incorporation within the defect. The same group possessed higher amounts of bone graft material within the defect throughout the 8-week observation period, whereas the other groups seemed to decrease in volume from 4 to 8 weeks. Conclusion: Changing the PLGA percentage to 35% within the biphasic graft material seemed to maintain its volume and prevented soft tissue migration, which could be clinically beneficial.

Original languageEnglish (US)
Pages (from-to)149-154
Number of pages6
JournalImplant dentistry
Issue number2
StatePublished - Apr 4 2015


  • bone grafts
  • histomorphometry
  • hydroxyapatite
  • poly-lactic-co-glycolic acid
  • tricalcium phosphate

ASJC Scopus subject areas

  • Oral Surgery


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