Boundary and medial shape analysis of the hippocampus in schizophrenia

Martin Styner; Jeffrey A. Lieberman; Dimitrios Pantazis; Guido Gerig

doi:10.1016/j.media.2004.06.004

Boundary and medial shape analysis of the hippocampus in schizophrenia

Martin Styner, Jeffrey A. Lieberman, Dimitrios Pantazis, Guido Gerig

Research output: Contribution to journal › Article › peer-review

Abstract

Statistical shape analysis has become of increasing interest to the neuroimaging community due to its potential to precisely locate morphological changes and thus potentially discriminate between healthy and pathological structures. This paper describes a combined boundary and medial shape analysis based on two different shape descriptions applied to a study of the hippocampus shape abnormalities in schizophrenia. The first shape description is the sampled boundary implied by the spherical harmonic SPHARM description. The second one is the medial shape description called M-rep. Both descriptions are sampled descriptions with inherent point correspondence. Their shape analysis is based on computing differences from an average template structure analyzed using standard group mean difference tests. The results of the global and local shape analysis in the presented hippocampus study exhibit the same patterns for the boundary and the medial analysis. The results strongly suggest that the normalized hippocampal shape of the schizophrenic group is different from the control group, most significantly as a deformation difference in the tail region.

Original language	English (US)
Pages (from-to)	197-203
Number of pages	7
Journal	Medical Image Analysis
Volume	8
Issue number	3
DOIs	https://doi.org/10.1016/j.media.2004.06.004
State	Published - Sep 2004

Keywords

Brain morphometry
Medial shape description
Medical image analysis
Schizophrenia
Shape analysis

ASJC Scopus subject areas

Radiological and Ultrasound Technology
Radiology Nuclear Medicine and imaging
Computer Vision and Pattern Recognition
Health Informatics
Computer Graphics and Computer-Aided Design

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10.1016/j.media.2004.06.004

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@article{81d7d517f19145dbabca70511d74b5f8,

title = "Boundary and medial shape analysis of the hippocampus in schizophrenia",

abstract = "Statistical shape analysis has become of increasing interest to the neuroimaging community due to its potential to precisely locate morphological changes and thus potentially discriminate between healthy and pathological structures. This paper describes a combined boundary and medial shape analysis based on two different shape descriptions applied to a study of the hippocampus shape abnormalities in schizophrenia. The first shape description is the sampled boundary implied by the spherical harmonic SPHARM description. The second one is the medial shape description called M-rep. Both descriptions are sampled descriptions with inherent point correspondence. Their shape analysis is based on computing differences from an average template structure analyzed using standard group mean difference tests. The results of the global and local shape analysis in the presented hippocampus study exhibit the same patterns for the boundary and the medial analysis. The results strongly suggest that the normalized hippocampal shape of the schizophrenic group is different from the control group, most significantly as a deformation difference in the tail region.",

keywords = "Brain morphometry, Medial shape description, Medical image analysis, Schizophrenia, Shape analysis",

author = "Martin Styner and Lieberman, {Jeffrey A.} and Dimitrios Pantazis and Guido Gerig",

note = "Funding Information: We are thankful to Christian Brechb{\"u}hler for providing the SPHARM software, to Steve Pizer and Sarang Joshi of the UNC MIDAG group for providing M-rep tools, to Scott Schobel for segmenting the hippocampi and to Maya Styner for editorial assistance. The hippocampal schizophrenia study was funded by the Stanley Foundation. This work was also funded by NCI Grant CA No. 47982 and NIMH Grant No. P30-MH33127.",

year = "2004",

month = sep,

doi = "10.1016/j.media.2004.06.004",

language = "English (US)",

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pages = "197--203",

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AU - Styner, Martin

AU - Lieberman, Jeffrey A.

AU - Pantazis, Dimitrios

AU - Gerig, Guido

N1 - Funding Information: We are thankful to Christian Brechbühler for providing the SPHARM software, to Steve Pizer and Sarang Joshi of the UNC MIDAG group for providing M-rep tools, to Scott Schobel for segmenting the hippocampi and to Maya Styner for editorial assistance. The hippocampal schizophrenia study was funded by the Stanley Foundation. This work was also funded by NCI Grant CA No. 47982 and NIMH Grant No. P30-MH33127.

PY - 2004/9

Y1 - 2004/9

N2 - Statistical shape analysis has become of increasing interest to the neuroimaging community due to its potential to precisely locate morphological changes and thus potentially discriminate between healthy and pathological structures. This paper describes a combined boundary and medial shape analysis based on two different shape descriptions applied to a study of the hippocampus shape abnormalities in schizophrenia. The first shape description is the sampled boundary implied by the spherical harmonic SPHARM description. The second one is the medial shape description called M-rep. Both descriptions are sampled descriptions with inherent point correspondence. Their shape analysis is based on computing differences from an average template structure analyzed using standard group mean difference tests. The results of the global and local shape analysis in the presented hippocampus study exhibit the same patterns for the boundary and the medial analysis. The results strongly suggest that the normalized hippocampal shape of the schizophrenic group is different from the control group, most significantly as a deformation difference in the tail region.

AB - Statistical shape analysis has become of increasing interest to the neuroimaging community due to its potential to precisely locate morphological changes and thus potentially discriminate between healthy and pathological structures. This paper describes a combined boundary and medial shape analysis based on two different shape descriptions applied to a study of the hippocampus shape abnormalities in schizophrenia. The first shape description is the sampled boundary implied by the spherical harmonic SPHARM description. The second one is the medial shape description called M-rep. Both descriptions are sampled descriptions with inherent point correspondence. Their shape analysis is based on computing differences from an average template structure analyzed using standard group mean difference tests. The results of the global and local shape analysis in the presented hippocampus study exhibit the same patterns for the boundary and the medial analysis. The results strongly suggest that the normalized hippocampal shape of the schizophrenic group is different from the control group, most significantly as a deformation difference in the tail region.

KW - Brain morphometry

KW - Medial shape description

KW - Medical image analysis

KW - Schizophrenia

KW - Shape analysis

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Boundary and medial shape analysis of the hippocampus in schizophrenia

Abstract

Keywords

ASJC Scopus subject areas

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