Boundary and medial shape analysis of the hippocampus in schizophrenia

Martin Styner, Jeffrey A. Lieberman, Dimitrios Pantazis, Guido Gerig

    Research output: Contribution to journalArticlepeer-review


    Statistical shape analysis has become of increasing interest to the neuroimaging community due to its potential to precisely locate morphological changes and thus potentially discriminate between healthy and pathological structures. This paper describes a combined boundary and medial shape analysis based on two different shape descriptions applied to a study of the hippocampus shape abnormalities in schizophrenia. The first shape description is the sampled boundary implied by the spherical harmonic SPHARM description. The second one is the medial shape description called M-rep. Both descriptions are sampled descriptions with inherent point correspondence. Their shape analysis is based on computing differences from an average template structure analyzed using standard group mean difference tests. The results of the global and local shape analysis in the presented hippocampus study exhibit the same patterns for the boundary and the medial analysis. The results strongly suggest that the normalized hippocampal shape of the schizophrenic group is different from the control group, most significantly as a deformation difference in the tail region.

    Original languageEnglish (US)
    Pages (from-to)197-203
    Number of pages7
    JournalMedical Image Analysis
    Issue number3
    StatePublished - Sep 2004


    • Brain morphometry
    • Medial shape description
    • Medical image analysis
    • Schizophrenia
    • Shape analysis

    ASJC Scopus subject areas

    • Radiological and Ultrasound Technology
    • Radiology Nuclear Medicine and imaging
    • Computer Vision and Pattern Recognition
    • Health Informatics
    • Computer Graphics and Computer-Aided Design


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