TY - JOUR
T1 - Brain functional connectivity in lung cancer population
T2 - an exploratory study
AU - Simó, M.
AU - Rifà-Ros, X.
AU - Vaquero, L.
AU - Ripollés, P.
AU - Cayuela, N.
AU - Jové, J.
AU - Navarro, A.
AU - Cardenal, F.
AU - Bruna, J.
AU - Rodríguez-Fornells, Antoni
N1 - Funding Information:
Funding This work was supported by la Fundació Marató-TV3 [Acquired Spinal Cord and Brain Injuries Program (2012–2015) awarded to ARF] and Hospital of Bellvitge Research Award 2016. Marta Simó is a recipient of a Juan Rodés contract from the Carlos III National Health Institute (Spanish Government)-European Social Fund (ESF).
Funding Information:
M. Sim? and X. Rif?-Ros contributed equally to this work J. Bruna and A. Rodr?guez-Fornells share co-senior authorship This work was supported by la Fundaci? Marat?-TV3 [Acquired Spinal Cord and Brain Injuries Program (2012?2015) awarded to ARF] and Hospital of Bellvitge Research Award 2016. Marta Sim? is a recipient of a Juan Rod?s contract from the Carlos III National Health Institute (Spanish Government)- European Social Fund (ESF).
Publisher Copyright:
© 2017, Springer Science+Business Media New York.
PY - 2018/4/1
Y1 - 2018/4/1
N2 - The present study aimed to explore the functional connectivity differences in Resting State Networks (RSNs) induced by cancer and chemotherapy in Lung Cancer (LC) patients using an Independent Component Analysis (ICA). Three matched groups of 15 LC patients following Chemotherapy (C+), 15 LC patients before Chemotherapy (C-) and 15 Healthy Controls (HC) were included. Analysis was performed using ICA and a multivariate pattern analysis (MVPA) to classify groups based on profiles of functional connectivity. We found significant differences in four of the RSN identified: Default Mode Network (DMN), Predominantly Left and Right Anterior Temporal Network, and Cerebellum Network. Whereas DMN showed decreased connectivity, the other RSNs exhibited increased connectivity in both LC groups compared to HC and in C+ in comparison to C-. MVPA discriminated significantly and accurately between all groups. Our study showed that disrupted functional connectivity associated with cancer and chemotherapy-induced cognitive deficits is not only related to DMN decreased connectivity abnormalities but also to an increased connectivity of other RSNs, suggesting a potential compensatory mechanism. [Figure not available: see fulltext.].
AB - The present study aimed to explore the functional connectivity differences in Resting State Networks (RSNs) induced by cancer and chemotherapy in Lung Cancer (LC) patients using an Independent Component Analysis (ICA). Three matched groups of 15 LC patients following Chemotherapy (C+), 15 LC patients before Chemotherapy (C-) and 15 Healthy Controls (HC) were included. Analysis was performed using ICA and a multivariate pattern analysis (MVPA) to classify groups based on profiles of functional connectivity. We found significant differences in four of the RSN identified: Default Mode Network (DMN), Predominantly Left and Right Anterior Temporal Network, and Cerebellum Network. Whereas DMN showed decreased connectivity, the other RSNs exhibited increased connectivity in both LC groups compared to HC and in C+ in comparison to C-. MVPA discriminated significantly and accurately between all groups. Our study showed that disrupted functional connectivity associated with cancer and chemotherapy-induced cognitive deficits is not only related to DMN decreased connectivity abnormalities but also to an increased connectivity of other RSNs, suggesting a potential compensatory mechanism. [Figure not available: see fulltext.].
KW - Chemotherapy
KW - Default mode network
KW - Functional connectivity
KW - Lung cancer
KW - Resting-state functional magnetic resonance imaging
KW - Prospective Studies
KW - Brain Mapping/methods
KW - Humans
KW - Middle Aged
KW - Male
KW - Cognition Disorders/diagnostic imaging
KW - Neural Pathways/diagnostic imaging
KW - Lung Neoplasms/diagnostic imaging
KW - Neuropsychological Tests
KW - Brain/diagnostic imaging
KW - Magnetic Resonance Imaging
KW - Rest
KW - Antineoplastic Agents/adverse effects
KW - Female
KW - Platinum Compounds/adverse effects
UR - http://www.scopus.com/inward/record.url?scp=85015090856&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85015090856&partnerID=8YFLogxK
U2 - 10.1007/s11682-017-9697-8
DO - 10.1007/s11682-017-9697-8
M3 - Article
C2 - 28290076
AN - SCOPUS:85015090856
SN - 1931-7557
VL - 12
SP - 369
EP - 382
JO - Brain Imaging and Behavior
JF - Brain Imaging and Behavior
IS - 2
ER -