Brain lesion segmentation through physical model estimation

Marcel Prastawa, Guido Gerig

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Segmentations of brain lesions from Magnetic Resonance (MR) images is crucial for quantitative analysis of lesion populations in neuroimaging of neurological disorders. We propose a new method for segmenting lesions in brain MRI by inferring the underlying physical models for pathology. We use the reaction-diffusion model as our physical model, where the diffusion process is guided by real diffusion tensor fields that are obtained from Diffusion Tensor Imaging (DTI). The method perorms segmentation by solving the inverse problem, where it determines the optimal parameters for the physical model that generates the observed image. We show that the proposed method can infer reasonable models for multiple sclerosis (MS) lesions and healthy MRI data. The method has potential for further extensions with different physical models or even non-physical models based on existing segmentation schemes.

Original languageEnglish (US)
Title of host publicationAdvances in Visual Computing - 4th International Symposium, ISVC 2008, Proceedings
Number of pages10
EditionPART 1
StatePublished - 2008
Event4th International Symposium on Visual Computing, ISVC 2008 - Las Vegas, NV, United States
Duration: Dec 1 2008Dec 3 2008

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
NumberPART 1
Volume5358 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349


Other4th International Symposium on Visual Computing, ISVC 2008
Country/TerritoryUnited States
CityLas Vegas, NV

ASJC Scopus subject areas

  • Theoretical Computer Science
  • General Computer Science


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