TY - JOUR
T1 - Brain structure and dynamics across scales
T2 - In search of rules
AU - Wang, Xiao Jing
AU - Kennedy, Henry
N1 - Publisher Copyright:
© 2016 Elsevier Ltd.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Louis Henry Sullivan, the father of skyscrapers, famously stated 'Form ever follows function'. In this short review, we will focus on the relationship between form (structure) and function (dynamics) in the brain. We summarize recent advances on the quantification of directed- and weighted-mesoscopic connectivity of mammalian cortex, the exponential distance rule for mesoscopic and microscopic circuit wiring, a spatially embedded random model of inter-areal cortical networks, and a large-scale dynamical circuit model of money's cortex that gives rise to a hierarchy of timescales. These findings demonstrate that inter-areal cortical networks are dense (hence such concepts as 'small-world' need to be refined when applied to the brain), spatially dependent (therefore purely topological approach of graph theory has limited applicability) and heterogeneous (consequently cortical areas cannot be treated as identical 'nodes').
AB - Louis Henry Sullivan, the father of skyscrapers, famously stated 'Form ever follows function'. In this short review, we will focus on the relationship between form (structure) and function (dynamics) in the brain. We summarize recent advances on the quantification of directed- and weighted-mesoscopic connectivity of mammalian cortex, the exponential distance rule for mesoscopic and microscopic circuit wiring, a spatially embedded random model of inter-areal cortical networks, and a large-scale dynamical circuit model of money's cortex that gives rise to a hierarchy of timescales. These findings demonstrate that inter-areal cortical networks are dense (hence such concepts as 'small-world' need to be refined when applied to the brain), spatially dependent (therefore purely topological approach of graph theory has limited applicability) and heterogeneous (consequently cortical areas cannot be treated as identical 'nodes').
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U2 - 10.1016/j.conb.2015.12.010
DO - 10.1016/j.conb.2015.12.010
M3 - Review article
C2 - 26868043
AN - SCOPUS:84957080079
SN - 0959-4388
VL - 37
SP - 92
EP - 98
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
ER -