Breakthroughs and Applications of Organ-on-a-Chip Technology

Mufeeda C. Koyilot; Priyadarshini Natarajan; Clayton R. Hunt; Sonish Sivarajkumar; Romy Roy; Shreeram Joglekar; Shruti Pandita; Carl W. Tong; Shamsudheen Marakkar; Lakshminarayanan Subramanian; Shalini S. Yadav; Anoop V. Cherian; Tej K. Pandita; Khader Shameer; Kamlesh K. Yadav

doi:10.3390/cells11111828

Breakthroughs and Applications of Organ-on-a-Chip Technology

Mufeeda C. Koyilot, Priyadarshini Natarajan, Clayton R. Hunt, Sonish Sivarajkumar, Romy Roy, Shreeram Joglekar, Shruti Pandita, Carl W. Tong, Shamsudheen Marakkar, Lakshminarayanan Subramanian, Shalini S. Yadav, Anoop V. Cherian, Tej K. Pandita, Khader Shameer, Kamlesh K. Yadav

Computer Science

Research output: Contribution to journal › Review article › peer-review

Abstract

Organ-on-a-chip (OOAC) is an emerging technology based on microfluid platforms and in vitro cell culture that has a promising future in the healthcare industry. The numerous ad-vantages of OOAC over conventional systems make it highly popular. The chip is an innovative combination of novel technologies, including lab-on-a-chip, microfluidics, biomaterials, and tissue engineering. This paper begins by analyzing the need for the development of OOAC followed by a brief introduction to the technology. Later sections discuss and review the various types of OOACs and the fabrication materials used. The implementation of artificial intelligence in the system makes it more advanced, thereby helping to provide a more accurate diagnosis as well as convenient data management. We introduce selected OOAC projects, including applications to organ/disease mod-elling, pharmacology, personalized medicine, and dentistry. Finally, we point out certain challenges that need to be surmounted in order to further develop and upgrade the current systems.

Original language	English (US)
Article number	1828
Journal	Cells
Volume	11
Issue number	11
DOIs	https://doi.org/10.3390/cells11111828
State	Published - Jun 1 2022

Keywords

heart
kidney
liver
lung
organ-on-a-chip
technology

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.3390/cells11111828

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title = "Breakthroughs and Applications of Organ-on-a-Chip Technology",

abstract = "Organ-on-a-chip (OOAC) is an emerging technology based on microfluid platforms and in vitro cell culture that has a promising future in the healthcare industry. The numerous ad-vantages of OOAC over conventional systems make it highly popular. The chip is an innovative combination of novel technologies, including lab-on-a-chip, microfluidics, biomaterials, and tissue engineering. This paper begins by analyzing the need for the development of OOAC followed by a brief introduction to the technology. Later sections discuss and review the various types of OOACs and the fabrication materials used. The implementation of artificial intelligence in the system makes it more advanced, thereby helping to provide a more accurate diagnosis as well as convenient data management. We introduce selected OOAC projects, including applications to organ/disease mod-elling, pharmacology, personalized medicine, and dentistry. Finally, we point out certain challenges that need to be surmounted in order to further develop and upgrade the current systems.",

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year = "2022",

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language = "English (US)",

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AU - Koyilot, Mufeeda C.

AU - Natarajan, Priyadarshini

AU - Hunt, Clayton R.

AU - Sivarajkumar, Sonish

AU - Roy, Romy

AU - Joglekar, Shreeram

AU - Pandita, Shruti

AU - Tong, Carl W.

AU - Marakkar, Shamsudheen

AU - Subramanian, Lakshminarayanan

AU - Yadav, Shalini S.

AU - Cherian, Anoop V.

AU - Pandita, Tej K.

AU - Shameer, Khader

AU - Yadav, Kamlesh K.

PY - 2022/6/1

Y1 - 2022/6/1

N2 - Organ-on-a-chip (OOAC) is an emerging technology based on microfluid platforms and in vitro cell culture that has a promising future in the healthcare industry. The numerous ad-vantages of OOAC over conventional systems make it highly popular. The chip is an innovative combination of novel technologies, including lab-on-a-chip, microfluidics, biomaterials, and tissue engineering. This paper begins by analyzing the need for the development of OOAC followed by a brief introduction to the technology. Later sections discuss and review the various types of OOACs and the fabrication materials used. The implementation of artificial intelligence in the system makes it more advanced, thereby helping to provide a more accurate diagnosis as well as convenient data management. We introduce selected OOAC projects, including applications to organ/disease mod-elling, pharmacology, personalized medicine, and dentistry. Finally, we point out certain challenges that need to be surmounted in order to further develop and upgrade the current systems.

AB - Organ-on-a-chip (OOAC) is an emerging technology based on microfluid platforms and in vitro cell culture that has a promising future in the healthcare industry. The numerous ad-vantages of OOAC over conventional systems make it highly popular. The chip is an innovative combination of novel technologies, including lab-on-a-chip, microfluidics, biomaterials, and tissue engineering. This paper begins by analyzing the need for the development of OOAC followed by a brief introduction to the technology. Later sections discuss and review the various types of OOACs and the fabrication materials used. The implementation of artificial intelligence in the system makes it more advanced, thereby helping to provide a more accurate diagnosis as well as convenient data management. We introduce selected OOAC projects, including applications to organ/disease mod-elling, pharmacology, personalized medicine, and dentistry. Finally, we point out certain challenges that need to be surmounted in order to further develop and upgrade the current systems.

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Breakthroughs and Applications of Organ-on-a-Chip Technology

Abstract

Keywords

ASJC Scopus subject areas

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