TY - JOUR
T1 - Brownian motion of nucleated cell envelopes impedes adhesion
AU - Zidovska, Alexandra
AU - Sackmann, Erich
PY - 2006
Y1 - 2006
N2 - We demonstrate that composite envelopes of nucleated cells exhibit pronounced short wavelength (â‰0.5Îm) bending excitations of â10nm root mean square amplitudes at physiological temperatures, which impede strong adhesion due to entropic repulsion forces. Quantitative microinterferometric analysis of the dynamic cell surface roughness of macrophages in terms of the theory of statistical surfaces suggests that the membrane excitations are mainly thermally driven Brownian motions (although active driving forces may contribute substantially). We determine the effective bending modulus of the cell envelope (â1000kBT), the cortical tension (â10-4Nm-1), and the work of adhesion (â10-5Jm-2).
AB - We demonstrate that composite envelopes of nucleated cells exhibit pronounced short wavelength (â‰0.5Îm) bending excitations of â10nm root mean square amplitudes at physiological temperatures, which impede strong adhesion due to entropic repulsion forces. Quantitative microinterferometric analysis of the dynamic cell surface roughness of macrophages in terms of the theory of statistical surfaces suggests that the membrane excitations are mainly thermally driven Brownian motions (although active driving forces may contribute substantially). We determine the effective bending modulus of the cell envelope (â1000kBT), the cortical tension (â10-4Nm-1), and the work of adhesion (â10-5Jm-2).
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U2 - 10.1103/PhysRevLett.96.048103
DO - 10.1103/PhysRevLett.96.048103
M3 - Article
C2 - 16486899
AN - SCOPUS:33144457671
SN - 0031-9007
VL - 96
JO - Physical Review Letters
JF - Physical Review Letters
IS - 4
M1 - 048103
ER -